Furosemide Stress Test Predicting Early Graft Function in Kidney Transplantation
FOSTIK
Furosemide Stress Test as a Marker of Postoperative Kidney Allograft Function
1 other identifier
interventional
180
1 country
1
Brief Summary
Furosemide is an old drug that has been used frequently in the postoperative period of kidney transplantation, aiming to achieve adequate urine output. There is no previous study that directly evaluate the urine response to standardized dose of furosemide in the postoperative period. The objective is to measure the urine output after standardized dose of furosemide is delivered, as a biomarker to predict the graft function in perioperative period.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
Started Nov 2016
Longer than P75 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
November 25, 2016
CompletedFirst Submitted
Initial submission to the registry
February 20, 2017
CompletedFirst Posted
Study publicly available on registry
March 7, 2017
CompletedPrimary Completion
Last participant's last visit for primary outcome
May 1, 2026
CompletedStudy Completion
Last participant's last visit for all outcomes
May 1, 2027
ExpectedJanuary 17, 2024
January 1, 2024
9.4 years
February 20, 2017
January 15, 2024
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Urine output
Urine output per hour (milliliters/hour) after furosemide injection
6 hours
Secondary Outcomes (2)
Delayed graft function
7 days
Creatinine reduction ratio
At postoperative day 0,7 and 14
Study Arms (1)
Furosemide
EXPERIMENTALSingle dose of furosemide 1.5 mg/kg intravenously will be given to all participants at 3 hours post-reperfusion of kidney allograft. Urine output will be recorded hourly for 6 hours.
Interventions
Furosemide 1.5 mg/kg intravenously at 3 hours post-reperfusion of kidney allograft
Eligibility Criteria
You may qualify if:
- Deceased donor kidney transplantation at KCMH
- informed consent is accepted
You may not qualify if:
- Known allergy to furosemide
- Surgical complication of allograft
- Urgently needed for dialysis (refractory hypervolemia, uremic symptoms, and hyperkalemia)
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
King Chulalongkorn Memorial Hospital
Bangkok, 10330, Thailand
Related Publications (1)
Udomkarnjananun S, Townamchai N, Iampenkhae K, Petchlorlian A, Srisawat N, Katavetin P, Sutherasan M, Santingamkun A, Praditpornsilpa K, Eiam-Ong S, Avihingsanon Y. Furosemide Stress Test as a Predicting Biomarker for Delayed Graft Function in Kidney Transplantation. Nephron. 2019;141(4):236-248. doi: 10.1159/000495765. Epub 2019 Jan 11.
PMID: 30636249DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
suwasin udomkarnjananun, M.D.
King Chulalongkorn Memorial Hospital and Chulalongkorn University
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NA
- Masking
- NONE
- Purpose
- DIAGNOSTIC
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Suwasin Udomkarnjananun, M.D.
Study Record Dates
First Submitted
February 20, 2017
First Posted
March 7, 2017
Study Start
November 25, 2016
Primary Completion
May 1, 2026
Study Completion (Estimated)
May 1, 2027
Last Updated
January 17, 2024
Record last verified: 2024-01