Effect of Atmospheric Pollution on Obstructive Lung Diseases

NCT03059459 | Unknown DMC

• 1 other identifier: 2919/1191/15
• Study Type: observational
• Target: 117
• Locations: 0 countries
• Sites: N/A

Brief Summary

Several studies have demonstrated the association between atmospheric pollution and chronic respiratory diseases. The magnitude of this association and its dependence of local factors are still unknown in Argentina, particularly for obstructive lung diseases like asthma and chronic obstructive pulmonary disease (COPD). The objective of this study is to assess the effect of atmospheric pollution due to particulate matter (PM) on asthma and COPD exacerbations in adults. A prospective cohort study will be carried out in patients attending the pulmonary service of a public hospital located in San Nicolas, Buenos Aires province, Argentina. Patients will be followed for 12 months after recruitment. The outcome variables will be the frequency of hospitalizations or emergency department consults for asthma or COPD exacerbations and related conditions, and the impact of COPD on a person's life as measured by the COPD assessment test (CAT) questionnaire. The exposure will be the pollution level in the particular address, measuring PM10 concentrations with portable equipment. Other variables as air temperature, humidity, and individual patient risk factors will be considered as potential confounders or effect modifiers. The associations will be estimated through regression models, i.e. logistic and Poisson regressions and recurrent event survival analysis. The results of this study should provide elements to estimate the risk of chronic respiratory diseases associated with atmospheric pollution, and to evaluate strategies for risk assessment in the local community.

Conditions

Lung Diseases, Obstructive

Keywords

Lung Diseases, Obstructive; Air Pollution; Particulate Matter

Outcome Measures

Primary Outcomes (1)

• Asthma or COPD hospitalizations or emergency department visits

  Asthma or COPD hospitalizations or emergency department visits measured by hospital records

  12 months

Secondary Outcomes (1)

• Quality of life associated with obstructive lung diseases

  12 months

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients attending the pulmonary service of a public hospital located in San Nicolas, Buenos Aires province, Argentina.

You may qualify if:

• Patients with asthma or COPD attending the pulmonary service.

You may not qualify if:

• Patients who refuse to participate in this study or to sign the informed consent document.

Sponsors & Collaborators

• National Council of Scientific and Technical Research, Argentina: lead

MeSH Terms

Conditions

Lung Diseases, Obstructive

Condition Hierarchy (Ancestors)

Lung Diseases; Respiratory Tract Diseases

Study Officials

• Pablo Orellano, Dr.PH

  National Scientific and Technical Research Council, Argentina

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Researcher

Study Record Dates

• First Submitted: February 15, 2017
• First Posted: February 23, 2017
• Study Start: December 4, 2015
• Primary Completion: December 4, 2018
• Study Completion: December 4, 2018
• Last Updated: January 25, 2018

Record last verified: 2018-01

Data Sharing

• IPD Sharing: Will not share