NCT03059394

Brief Summary

The aim of the study is to evaluate the psychometric properties (content and construct validity, reliability, measurements error, as well as possible floor and ceiling effects) of both the assessments MMT8 and the myositis activity profile in patients with IM.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
50

participants targeted

Target at P25-P50 for all trials

Timeline
Completed

Started Mar 2014

Typical duration for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

March 1, 2014

Completed
1.4 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 1, 2015

Completed
9 months until next milestone

Study Completion

Last participant's last visit for all outcomes

May 1, 2016

Completed
9 months until next milestone

First Submitted

Initial submission to the registry

February 9, 2017

Completed
14 days until next milestone

First Posted

Study publicly available on registry

February 23, 2017

Completed
Last Updated

February 23, 2017

Status Verified

February 1, 2017

Enrollment Period

1.4 years

First QC Date

February 9, 2017

Last Update Submit

February 20, 2017

Conditions

Keywords

reliabilityvaliditymeasurement error

Outcome Measures

Primary Outcomes (1)

  • Manual Muscle Testing 8 (MMT8)

    The strength of 8 Muscle groups is tested in a defined position and rewarded with a score varying from 0 (No visible movement) to 10 (holds test position against strong pressure) and summed for a potential score from 0-80.

    15 minutes

Secondary Outcomes (11)

  • Quantitative Muscle Testing

    15 Minutes

  • Functional Index 2

    30 minutes

  • Functional Test Battery (FTB): Test 1 Self-Performed Physical Performance Test.

    Total FTB: 1 1/4 hours

  • Functional Test Battery (FTB): Balance Test

    Total FTB: 1 1/4 hours

  • Functional Test Battery ( FTB): Walk test ( 4 m)

    Total FTB: 1 1/4 hours

  • +6 more secondary outcomes

Interventions

Test - Retest of measurements

Also known as: Test retest study

Eligibility Criteria

Age18 Years+
Sexall
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

1. Patients with diagnosed inflammatory myopathy 2. Age and gender matched controls

You may qualify if:

  • Diagnosis of polymyositis or dermatomyositis or inflammatory myositis associated disorders (e.g. Scleroderma, Systematic lupus erythematosus, Sjögren's syndrome)
  • Age over 18
  • Sufficiently understanding of German language
  • able to understand and follow verbal and written instructions
  • signed informed consent to participate in the study

You may not qualify if:

  • Pulmonary hypertension
  • Osteoporosis
  • Severe cardiovascular and/or pulmonary disease
  • Pain syndrome
  • Paresis
  • Age over 18
  • Sufficiently understanding of German language
  • able to understand and follow verbal and written instructions
  • signed informed consent to participate in the study

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University Hospital Zurich

Zurich, 8091, Switzerland

Location

MeSH Terms

Conditions

Myositis

Condition Hierarchy (Ancestors)

Muscular DiseasesMusculoskeletal DiseasesNeuromuscular DiseasesNervous System Diseases

Study Officials

  • Baschung Pfister Pierrette, MPH

    University of Zurich

    STUDY CHAIR

Study Design

Study Type
observational
Observational Model
OTHER
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

February 9, 2017

First Posted

February 23, 2017

Study Start

March 1, 2014

Primary Completion

August 1, 2015

Study Completion

May 1, 2016

Last Updated

February 23, 2017

Record last verified: 2017-02

Locations