rTMS in Facilitation of Working Memory in PD
1 other identifier
interventional
60
1 country
1
Brief Summary
Ten sessions of repetitive transcranial magnetic stimulation yield ability to upregulate the function of primary motor cortex and prefrontal cortex that play key roles in motor and frontal memory processing.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable parkinson-disease
Started Oct 2017
Longer than P75 for not_applicable parkinson-disease
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
January 16, 2017
CompletedFirst Posted
Study publicly available on registry
February 23, 2017
CompletedStudy Start
First participant enrolled
October 30, 2017
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2021
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2021
CompletedJanuary 8, 2021
January 1, 2021
4.1 years
January 16, 2017
January 5, 2021
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Change of Repeatable Battery for the Assessment of Neuropsychological Status
This battery measures the cognitive functions including attention, memory, language, visuospatial domains.
up to 12 weeks
Secondary Outcomes (1)
Change of Montreal Cognitive Assessment ; MoCA
up to 12 weeks
Study Arms (3)
High frequency rTMS
EXPERIMENTALReal rTMS, one session per day, for 10 days
High frequency rTMS with cognitive training
EXPERIMENTALReal rTMS and cognitive training, one session per day, for 10 days
Sham rTMS
SHAM COMPARATORSham rTMS, one session per day, for 10 days
Interventions
High frequency rTMS for 3 to 10 min to increase the excitability of cortex.
A rehabilitation protocol that facilitates attention, memory, execution.
Eligibility Criteria
You may qualify if:
- Clinical diagnosis of Parkinson's Disease
- With symptoms of cognitive impairments, such as memory, attention, or language decline.
You may not qualify if:
- History of seizure attack
- Alzheimer's disease
- With cardiac pacemaker implantation
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Taipei Veteran General Hospital
Taipei, 11217, Taiwan
Related Publications (1)
Preston G, Anderson E, Silva C, Goldberg T, Wassermann EM. Effects of 10 Hz rTMS on the neural efficiency of working memory. J Cogn Neurosci. 2010 Mar;22(3):447-56. doi: 10.1162/jocn.2009.21209.
PMID: 19309294RESULT
Related Links
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Po-Yi Tsai, MD
Taipei Veterans General Hospital, Taiwan
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER GOV
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- principal investigator
Study Record Dates
First Submitted
January 16, 2017
First Posted
February 23, 2017
Study Start
October 30, 2017
Primary Completion
December 1, 2021
Study Completion
December 1, 2021
Last Updated
January 8, 2021
Record last verified: 2021-01
Data Sharing
- IPD Sharing
- Will not share