Pain Mechanisms in Young Adolescent Females With Longstanding Patellofemoral Pain

NCT03051412 | Completed

• 1 other identifier: N-20160058 (1)
• Study Type: observational
• Target: 87
• Locations: 1 country
• Sites: 1

Brief Summary

Patellofemoral pain (PFP) is a highly prevalent musculoskeletal condition in adult females, which is associated with decreased quality of life and physical activity levels. PFP is highly persistent, with up to 50% of adolescents reporting persistent pain at both one and two year follow-ups. Previous research has demonstrated altered pain sensitivity in in older individuals with chronic pain, however, less is known about this in conditions such as PFP, which is common in younger populations. Additionally it is unknown if these characteristics return to similar values as healthy controls, when symptoms resolve. The aim of this study will be to compare pain sensitivity in individuals with PFP, compared to those with a previous history of PFP who currently are pain-free, and a control group with no history of knee pain.

Conditions

Patellofemoral Pain Syndrome; Pain

Outcome Measures

Primary Outcomes (1)

• Conditioned pain modulation

  Conditioned pain modulation (CPM) will be assessed using cuff algometry

  Baseline

Secondary Outcomes (4)

• Pressure pain thresholds will be measured around the lower leg and forearm

  baseline

• Pressure Pain thresholds at the knee

  baseline

• Temporal summation of pain

  baseline

• Pressure detection & pressure tolerance threshold assessed by cuff algometry

  baseline

Study Arms (3)

Current Patellofemoral Pain

This group has current patellofemoral pain

Other: No Intervention

Recovered

This group has a previous history of patellofemoral pain, but currently self reports as recovered.

Other: No Intervention

Control

This is a control group with no history of knee pain.

Other: No Intervention

Interventions

No Intervention OTHER

No intervention

Control; Current Patellofemoral Pain; Recovered

Eligibility Criteria

• Age: 18 Years - 30 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Probability Sample

Study Population

The study population will consist of young females. One group will include participants with current longstanding patellofemoral pain, while a second group will include those with a history of pain, who self report as recovered, and a control group, who has no previous history of knee pain.

You may qualify if:

• Female
• Age 18-30years
• Current longstanding patellofemoral pain

You may not qualify if:

• Patients who have sustained a traumatic injury to the hip, knee, ankle or the lumbar spine within the past 3 month will be excluded.
• Participants will be excluded if they have other diagnosable pathologies that can cause pain around the kneecap (patellatendinopathy, Osgood-Shlatter, iliotibial band syndrome, Sinding-Larsen-Johansson syndrome, reverse jumper) if they occur in isolation (without patellofemoral pain).
• Recovered Group:
• Previous history of patellofemoral pain, reporting no current knee pain
• Female
• Aged 18-30 years
• Participants will be excluded if they have other diagnosable pathologies that can cause pain around the kneecap (patellatendinopathi, Osgood-Shlatter, iliotibial band syndrome, Sinding-Larsen-Johansson syndrome, reverse jumper)
• Other pain conditions
• Control:
• Female
• Aged 18-30
• Current knee or other other musculoskeletal pain
• Previous history of knee or musculoskeletal pain

Sponsors & Collaborators

• Aalborg University: lead
• Research Unit for General Practice in Aalborg: collaborator

Study Sites (1)

Research Unit for General Practice in Aalborg

Aalborg, 9000, Denmark

Location

MeSH Terms

Conditions

Patellofemoral Pain Syndrome; Pain

Condition Hierarchy (Ancestors)

Joint Diseases; Musculoskeletal Diseases; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Sinead Holden, PhD

  Research Unit for General Practice, Department of Clinical Medicine, Aalborg University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Post- Doctoral Research Fellow

Study Record Dates

• First Submitted: February 9, 2017
• First Posted: February 13, 2017
• Study Start: February 22, 2017
• Primary Completion: August 31, 2017
• Study Completion: August 31, 2017
• Last Updated: November 14, 2017

Record last verified: 2017-11

Locations

DK (1)