Electrical Impedance Tomography of Epilepsy

NCT03050931 | Active Not Recruiting

• 1 other identifier: 14/0861a
• Study Type: observational
• Target: 42
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to determine if Electrical Impedance Tomography (EIT) can produce reproducible and accurate images in people with epilepsy compared to existing standards such as MRI, CT or EEG. Electrical Impedance Tomography is a relatively new medical imaging method, which has the potential to provide novel images of brain function. It is fast, portable, safe and inexpensive, but currently has a relatively poor spatial resolution. It produces images of the internal electrical impedance of a subject with epilepsy using rings of ECG like electrodes on the skin, intracranial electrode mats or deep electrodes implemented surgically as part of clinical assessment. EIT recording will take place in parallel with the routine recording on the ward. Following completion of the recording, the EIT images will subsequently be analysed and compared to other imaging data for accuracy.

Conditions

Epilepsy

Keywords

Electrical Impedance Tomography; EIT; Epilepsy

Outcome Measures

Primary Outcomes (1)

• EIT images accuracy

  three years

Study Arms (2)

Epilepsy with intracranial electrodes

Electrical Impedance Tomography with depth electrodes or intracranial electrode mats

Device: Electrical Impedance Tomography

Epilepsy with scalp electrodes

Electrical Impedance Tomography with scalp electrodes

Device: Electrical Impedance Tomography

Interventions

Electrical Impedance Tomography DEVICE

EIT comprises of a box of electronics similar in size to a video recorder, laptop computer and leads which link typically to 16 or 32 external ECG-like electrodes placed around the subject. Images are generated by applying tiny electrical signals through some electrodes and recording the resulting signals at others. The signals applied are completely safe, within established British and EU safety limits and cannot be felt. For intracranial electrode studies, the EIT systems will be linked to the existing EEG video recording systems and EIT will be recorded at the same time using some or all of the available intracranial electrodes.

Also known as: EIT

Epilepsy with intracranial electrodes; Epilepsy with scalp electrodes

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Epilepsy patients recruited from the patients of National Hospital for Neurology and Neurosurgery in London.

You may qualify if:

• Any patient with epilepsy with either active seizures or interictal EEG changes (for scalp electrodes group)
• Any patient with epilepsy with either active seizures under evaluation for epilepsy surgery (for intracranial electrodes group)
• Ability to give informed consent

You may not qualify if:

• none

Sponsors & Collaborators

• University College, London: lead
• University College London Hospitals: collaborator

Study Sites (1)

EEG telemetry unit Neurophysiology National Hospital for Neurology and Neurosurgery

London, WC1N 3BG, United Kingdom

Location

MeSH Terms

Conditions

Epilepsy

Condition Hierarchy (Ancestors)

Brain Diseases; Central Nervous System Diseases; Nervous System Diseases

Study Officials

• David S Holder, Professor

  University College London, University College Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 8, 2017
• First Posted: February 13, 2017
• Study Start: May 30, 2017
• Primary Completion (Estimated): December 1, 2027
• Study Completion (Estimated): December 1, 2027
• Last Updated: December 6, 2024

Record last verified: 2024-12

Locations

GB (1)