Clinical Trial of Light Therapy for Epilepsy
A Randomised Placebo Controlled Clinical Trial of Light Therapy for Medically Intractable Epilepsy.
1 other identifier
interventional
100
1 country
1
Brief Summary
This study is designed to investigate whether light therapy may be an effective treatment for some people with epilepsy. Light treatment is already an established treatment for depression. The chemical systems in the brain that are disrupted when someone becomes depressed, overlap with some of those that can be affected during some epileptic seizures. The investigators have designed this study to see whether light therapy may also lead to a decrease in seizures in people who have epilepsy. The study will be a placebo controlled trial. This means that half of the participants will receive a therapeutic dose of light therapy from a light box, whilst the other half will only receive a placebo light treatment.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable
Started Sep 2010
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
December 8, 2009
CompletedFirst Posted
Study publicly available on registry
December 9, 2009
CompletedStudy Start
First participant enrolled
September 1, 2010
CompletedPrimary Completion
Last participant's last visit for primary outcome
April 1, 2011
CompletedStudy Completion
Last participant's last visit for all outcomes
September 1, 2011
CompletedDecember 9, 2009
December 1, 2009
7 months
December 8, 2009
December 8, 2009
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Number of seizures/month
3 months
Secondary Outcomes (1)
Mood
3 months
Study Arms (2)
100 lux
PLACEBO COMPARATOR100 lux / 30 minutes day
Light Therapy 10,000 lux
EXPERIMENTAL10,000 lux / 30 minutes a day for 3 months
Interventions
10,000 lux / 30 minutes a day
Eligibility Criteria
You may qualify if:
- Adult
- Medically intractable epilepsy
- Min 4 complex partial seizures/ month
You may not qualify if:
- Ability to give informed consent
- Underlying progressive neurological condition
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- University College, Londonlead
- Action Medical Researchcollaborator
Study Sites (1)
National Hospital for Neurology & Neurosurgery
London, London, WC1N 3BG, United Kingdom
Related Publications (2)
Baxendale S, O'Sullivan J, Heaney D. Bright light therapy for symptoms of anxiety and depression in focal epilepsy: randomised controlled trial. Br J Psychiatry. 2013 May;202(5):352-6. doi: 10.1192/bjp.bp.112.122119. Epub 2013 Mar 21.
PMID: 23520221DERIVEDBaxendale S, O'Sullivan J, Heaney D. Bright light therapy as an add on treatment for medically intractable epilepsy. Epilepsy Behav. 2012 Jul;24(3):359-64. doi: 10.1016/j.yebeh.2012.04.123. Epub 2012 May 30.
PMID: 22658437DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
Study Record Dates
First Submitted
December 8, 2009
First Posted
December 9, 2009
Study Start
September 1, 2010
Primary Completion
April 1, 2011
Study Completion
September 1, 2011
Last Updated
December 9, 2009
Record last verified: 2009-12