Neuromuscular Fatigue Aetiology Comparison Between Prepubertal Boys and Adults
LENGTH-FATIG
LENGTH-FATIG
Sponsor study identifier
Secondary identifiers
OTHER · 2016-A00827-44
observational
50
1 country
1
Study Start
February 13, 2017
Actual (reported)Primary Completion
November 20, 2017
Actual (reported)Study Completion
November 20, 2017
Actual (reported)Potential factors involved in neuromuscular fatigue were classified into two categories: 1) central factors involving the central nervous system and neural pathways, and 2) peripheral factors occurring within the muscle beyond the neuromuscular junction. In adults, it has been shown that peripheral factors contribute to a large part of the fatigue induced by repeated maximal contractions. However in children, central factors could account for the development of fatigue to a greater extent. Force-generating capacity and musculotendinous stiffness could be two of the discriminatory factors accounting for the differences in the neuromuscular fatigue between children and adults. Force production capacity and musculotendinous stiffness vary as function of muscle length. Naturally, they could differ depending on the muscle groups studied. The main aim of the present protocol is to compare the effect of knee extensors and ankle plantarflexors length on the development and aetiology of neuromuscular fatigue, in children and adults. The investigators formulated the hypotheses that at short muscle length force and low musculotendinous stiffness, differences in force between children and adults would be reduced. Thus neuromuscular fatigue development and aetiology would be similar between both groups. The results of the present protocol will allow to better understanding of the aetiology of neuromuscular fatigue in children and help improving training or rehabilitation programs.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
November 20, 2017
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
February 3, 2017
Actual (reported)February 10, 2017
Actual (reported)February 13, 2017
Actual (reported)November 20, 2017
Actual (reported)November 20, 2017
Actual (reported)Maximal torque of knee extensors
once a week during six weeks.
ankle plantar flexors joint (in N.m) measured with a dynamometer.
once a week during six weeks.
Doublet torque amplitude (100Hz, in N.m) evoked using magnetic nerve stimulation at rest
once a week during six weeks.
Muscular tissue oxygenation (in μmol.L-1) measured at skin surface by Near-infrared spectroscopy.
once a week during six weeks
Compound muscle action potential amplitude (i.e. M-wave ; in mV) evoked by supramaximal magnetic nerve stimulation and measured by surface Electromyography (EMG).
once a week during six weeks
High frequency doublet (100Hz)/low frequency doublet (10Hz) ratio
once a week during six weeks
fascicule length (mm) measured by B-mode real time ultrasound scanner.
once a week during six weeks
The main aim of the present protocol is to compare the effect of knee extensors and ankle plantarflexors length on the development and aetiology of neuromuscular fatigue, in children and adults
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
prepubertal boys and adults
CHU Clermont-Ferrand
Clermont-Ferrand, 63003, France
Piponnier E, Martin V, Bontemps B, Chalchat E, Julian V, Bocock O, Duclos M, Ratel S. Child-adult differences in neuromuscular fatigue are muscle dependent. J Appl Physiol (1985). 2018 Oct 1;125(4):1246-1256. doi: 10.1152/japplphysiol.00244.2018. Epub 2018 Aug 9.
Martine DUCLOS
University Hospital, Clermont-Ferrand
50 participants (actual enrollment reported by the registry).
First Submitted
February 3, 2017
First Posted
February 10, 2017
Study Start
February 13, 2017
Actual (reported)Contact the study team to confirm eligibility.
Primary Completion
November 20, 2017
Actual (reported)Study Completion
November 20, 2017
Actual (reported)Last Updated
August 7, 2026
Record last verified: 2026-08
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Source: ClinicalTrials.gov.
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