Trials Sponsors Conditions Drugs Pricing

Conditions

Picoseconds Laser Melasma

Outcome Measures

Primary Outcomes (2)

Modified MASI score
The mean change from the baseline to week-12 visit
Proportion of subjects with at least 50% MASI score improvement
from baseline to 12-week visit

Secondary Outcomes (3)

Mexameter Melanin index
baseline, week 4, week 8 and week 12
Global satisfaction score by Quartile rating scale
week 4, week 8 and week 12
Quality of life by DLQI
at week 12

Study Arms (2)

Fractional Picosecond 1,064 nm laser and 4% hydroquinone cream

EXPERIMENTAL

Device: Fractional Picosecond 1,064 nm laserDrug: 4% hydroquinone cream

4% hydroquinone cream alone

ACTIVE COMPARATOR

Drug: 4% hydroquinone cream

Interventions

Fractional Picosecond 1,064 nm laserDevice

Fractional Picosecond 1,064 nm laser and daily application with 4% hydroquinone cream

Fractional Picosecond 1,064 nm laser and 4% hydroquinone cream

4% hydroquinone creamDrug

4% hydroquinone cream aloneFractional Picosecond 1,064 nm laser and 4% hydroquinone cream

Eligibility Criteria

Age18 Years - 65 Years

Sexfemale(Gender-based eligibility)

Gender Eligibility DetailsFemale

Healthy VolunteersYes

Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

Female with melasma lesion on bilateral sides

Sponsors & Collaborators

Mae Fah Luang University Hospital
Otherlead

Related Publications (2)

Ho C, Nguyen Q, Lowe NJ, Griffin ME, Lask G. Laser resurfacing in pigmented skin. Dermatol Surg. 1995 Dec;21(12):1035-7. doi: 10.1111/j.1524-4725.1995.tb00554.x.
PMID: 7496671BACKGROUND
Weiss M, Weiss R, Lorden F, Trageser M, Beasley K. Picosecond laser for reduction of wrinkles: Long term results. Lasers Surg Med 2015; 47(S26): 24 (Abstract #68).
BACKGROUND

MeSH Terms

Conditions

Melanosis

Interventions

Lasers

Condition Hierarchy (Ancestors)

HyperpigmentationPigmentation DisordersSkin DiseasesSkin and Connective Tissue Diseases

Intervention Hierarchy (Ancestors)

Optical DevicesEquipment and SuppliesRadiation Equipment and Supplies

Enrollment

30 participants (actual enrollment reported by the registry).

Study Design

Study Type: interventional
Phase: phase 2
Allocation: RANDOMIZED
Masking: SINGLE
Who Masked: OUTCOMES ASSESSOR
Purpose: TREATMENT
Intervention Model: PARALLEL
Sponsor Type: OTHER
Responsible Party: PRINCIPAL INVESTIGATOR
PI Title: Dr.

Study Record Dates

First Submitted

February 3, 2017

First Posted

February 9, 2017

Study Start

June 1, 2016

Actual (reported)

A Comparative Study for Efficacy and Safety Between 4% Hydroquinone Cream With or Without Fractional Picosecond 1,064 nm Laser for the Treatment of Dermal or Mixed Type Melasma

Brief Summary

Registry Overview

Trial Relationships

Study Timeline

Study Start

Primary Completion

Study Completion

First Submitted

First Posted

Conditions

Outcome Measures

Primary Outcomes (2)

Secondary Outcomes (3)

Study Arms (2)

Fractional Picosecond 1,064 nm laser and 4% hydroquinone cream

4% hydroquinone cream alone

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Related Publications (2)

MeSH Terms

Conditions

Interventions

Condition Hierarchy (Ancestors)

Intervention Hierarchy (Ancestors)

Enrollment

Study Design

Study Record Dates

You may not qualify if:

Data Sharing

Source record

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

Study Start

Primary Completion

Study Completion

First Submitted

First Posted

Conditions

Outcome Measures

Primary Outcomes (2)

Secondary Outcomes (3)

Study Arms (2)

Fractional Picosecond 1,064 nm laser and 4% hydroquinone cream

4% hydroquinone cream alone

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Related Publications (2)

MeSH Terms

Conditions

Interventions

Condition Hierarchy (Ancestors)

Intervention Hierarchy (Ancestors)

Enrollment

Study Design

Study Record Dates

You may not qualify if:

Data Sharing

Source record