HIT in Insulin-resistant and Insulin-sensitive Obese Adolescents

NCT03042234 | Completed DMC

• 3 other identifiers: japarecido34634414.5.0000.54791.227.250
• Study Type: interventional
• Target: 25
• Locations: 1 country
• Sites: 3

Brief Summary

Evaluate the effects of HIT on the cardiorespiratory performance and substrate oxidation of insulin-resistant and insulin-sensitive obese adolescents.

Conditions

Obesity; Insulin-resistant; Adolescents

Keywords

Obesity; Insulin-resistant; Adolescents; High-intensity interval training

Outcome Measures

Primary Outcomes (5)

• rate of Peak oxygen consumption (VOpeak)

  The cardiopulmonary test protocol for determination the VOpeak (ml/kg/min) included running on a treadmill (Model ATL, Inbrasport Ltda; Brazil) at a speed of 4 km/h with 1 km/h increments every minute until the participant showed exhaustion. We evaluated ventilatory parameters on a gas analyzer (model VO2000; Inbrasport Ltda; Brazil).

  4 weeks

• rate of Intensity at first ventilatory anaerobic threshold (VAT1)

  The cardiopulmonary test protocol included running on a treadmill (Model ATL, Inbrasport Ltda; Brazil) at a speed of 4 km/h with 1 km/h increments every minute until the participant showed exhaustion. We evaluated ventilatory parameters on a gas analyzer (model VO2000; Inbrasport Ltda; Brazil).We determined VAT1 (ml/kg/min) using the V-slope method of Beaver et al.

  4 weeks

• rate of Peak Heart rate

  The cardiopulmonary test protocol included treadmill running (Model ATL, Inbrasport Ltda; Brazil). speed of 4 km / h with increments of 1 km / h every minute until the participant shows exhaustion.

  4 weeks

• rate of carbohydrate oxidation

  The substrate oxidation pattern protocol included treadmill running (Model ATL, Inbrasport Ltda; Brazil),during continuous exercise of submaximal intensity (45 minutes of treadmill running at the intensity of the first ventilatory anaerobic threshold).

  4 weeks

• rate of lipid oxidation

  The substrate oxidation pattern protocol included treadmill running (Model ATL, Inbrasport Ltda; Brazil),during continuous exercise of submaximal intensity (45 minutes of treadmill running at the intensity of the first ventilatory anaerobic threshold).

  4 weeks

Study Arms (2)

Group Insulin-resistant

EXPERIMENTAL

Insulin-resistant obese adolescents

Other: Group Insulin-Resistant; Other: Group Insulin-Sensitive

Group Insulin-sensitive

EXPERIMENTAL

Insulin-sensitive obese adolescents

Other: Group Insulin-Resistant; Other: Group Insulin-Sensitive

Interventions

Group Insulin-Resistant OTHER

High intensity interval training: 3 to 6 sets of 60-second sprints at 100% of the peak velocity interspersed by a 3-min active recovery period.

Also known as: Insulin-resistant obese adolescents

Group Insulin-resistant; Group Insulin-sensitive

Group Insulin-Sensitive OTHER

High intensity interval training: 3 to 6 sets of 60-second sprints at 100% of the peak velocity interspersed by a 3-min active recovery period.

Also known as: Insulin-sensitive obese adolescents

Group Insulin-resistant; Group Insulin-sensitive

Eligibility Criteria

• Age: 12 Years - 16 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)

You may qualify if:

• aged 12-16 years
• with a body mass index z-score (zBMI) ≥ + 2SD
• puberty stage \> 3
• the boys and girls had to present a minimum physical fitness, according to the International Physical Activity Questionnaire (IPAQ), according to the activity performed during the last week and confirmed this using the peak cardiopulmonary test (VO2).

You may not qualify if:

• individuals undergoing drug treatment for weight control;
• indiviudals who had cardiac, orthopedic, respiratory or renal problems, diabetes, uncontrolled hypertension, genetic syndrome or hormonal abnormalities.

Sponsors & Collaborators

• Faculdade de Ciências Médicas da Santa Casa de São Paulo: lead

Study Sites (3)

Santa Casa of Sao Paulo School

São Paulo, 01221-020, Brazil

Location

Emef Angelina Maffei Vita

São Paulo, 02545-000, Brazil

Location

Emef Plinio Queroz

São Paulo, 08341-080, Brazil

Location

Related Publications (35)

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MeSH Terms

Conditions

Obesity

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Juliana Monique Lino Aparecido

  Faculdade de Ciências Médicas da Santa Casa de São Paulo

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal investigator Juliana Monique Lino Aparecido

Study Record Dates

• First Submitted: January 30, 2017
• First Posted: February 3, 2017
• Study Start: July 8, 2017
• Primary Completion: August 30, 2017
• Study Completion: November 2, 2018
• Last Updated: July 15, 2021

Record last verified: 2021-07

Locations

BR (3)