Depolarising Electrical Skin Stimulation in Neuropathic and Postoperative Pain
Selective Activation of Unmyelinated Skin Nerve Fibres Using Slow Depolarising Transcutaneous Electrical Stimulation in Patients With Neuropathic Pain or Chronic Postoperative Pain
1 other identifier
observational
75
1 country
1
Brief Summary
The aim of the study is to evaluate voltage gated sodium channel (NaV1.7) dependent pain phenomena in neuropathic pain and chronic postoperative pain.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Mar 2017
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
January 16, 2017
CompletedFirst Posted
Study publicly available on registry
January 31, 2017
CompletedStudy Start
First participant enrolled
March 27, 2017
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 31, 2025
CompletedStudy Completion
Last participant's last visit for all outcomes
December 31, 2025
CompletedDecember 8, 2025
December 1, 2025
8.8 years
January 16, 2017
December 1, 2025
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
change in pain intensity
numeric rating scale (NRS), rating from 0-10, 0=no pain, 10=maximum pain imaginable
at baseline and during electric nerve stimulation
Secondary Outcomes (16)
heat pain threshold
baseline
cold pain threshold
baseline
mechanical detection threshold
baseline
mechanical pain threshold
baseline
mechanical pain sensitivity
baseline
- +11 more secondary outcomes
Study Arms (2)
chronic pain
individuals suffering from chronic pain
neuropathic pain
individuals suffering from neuropathic pain
Interventions
electrophysiologic measurements of peripheral nerves
Eligibility Criteria
patients with neuropathic pain or with chronic postoperative pain
You may qualify if:
- Group (1) patients with neuropathic pain
- Group (2) patients with chronic postoperative pain
You may not qualify if:
- severe psychiatric disorder requiring hospitalisation in the past
- any neurological disease other than the pain diagnosis
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Centre for Pain Medicine
Nottwil, 6207, Switzerland
Related Publications (1)
Rolke R, Baron R, Maier C, Tolle TR, Treede -DR, Beyer A, Binder A, Birbaumer N, Birklein F, Botefur IC, Braune S, Flor H, Huge V, Klug R, Landwehrmeyer GB, Magerl W, Maihofner C, Rolko C, Schaub C, Scherens A, Sprenger T, Valet M, Wasserka B. Quantitative sensory testing in the German Research Network on Neuropathic Pain (DFNS): standardized protocol and reference values. Pain. 2006 Aug;123(3):231-243. doi: 10.1016/j.pain.2006.01.041. Epub 2006 May 11.
PMID: 16697110BACKGROUND
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- NETWORK
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
January 16, 2017
First Posted
January 31, 2017
Study Start
March 27, 2017
Primary Completion
December 31, 2025
Study Completion
December 31, 2025
Last Updated
December 8, 2025
Record last verified: 2025-12
Data Sharing
- IPD Sharing
- Will not share