Eosinophilic Granulomatosis With Polyangiitis Cohort

NCT03036670 | Completed

• 1 other identifier: PHT/2015/130
• Study Type: observational
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

EGPA (Eosinophilic Granulomatosis with Polyangiitis, previously Churg-Strauss syndrome) is a rare vasculitis, characterised by asthma, rhinosinusitis and eosinophilia. There has previously been confusion around diagnostic criteria, with multiple sets of classification criteria being used inappropriately for diagnosis. The ERS formed a taskforce to produce specific diagnostic criteria, and these divided the Churg-Strauss Syndrome cohort into two groups - vasculitic EGPA and tissular Hypereosinophilic Asthma with Systemic Manifestations (HASM). It is not known if the groups separated by the diagnostic criteria are also separated in clinical symptomatology, or if their disease course varies, and this could have significant impact on management and further research.

Conditions

Churg-Strauss Syndrome

Outcome Measures

Primary Outcomes (1)

• Diagnosis according to various diagnostic criteria

  The diagnosis of each participant according to different diagnostic or classification criteria (ERS-CSS, Chapel Hill, ACR, Lanham) based on all test results available between the point of diagnosis and 60 months later

  From date of diagnosis for 5 years

Secondary Outcomes (6)

• Corticosteroid dose

  From date of diagnosis for 5 years

• Immunosuppressive medication

  From date of diagnosis for 5 years

• Comorbid conditions

  From date of diagnosis for 5 years

• Biopsy findings

  From date of diagnosis for 5 years

• Relapse rates

  From date of diagnosis for 5 years

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Study participants are adults with Churg-Strauss syndrome under the care of Portsmouth Hospitals NHS Trust.

You may qualify if:

• Male or Female, aged 18 years or above.
• Cared for currently or previously cared for at Portsmouth Hospitals NHS Trust
• Diagnosed with EGPA/HASM according to clinicians

You may not qualify if:

• \- Medical notes not obtainable

Sponsors & Collaborators

• Portsmouth Hospitals NHS Trust: lead

Study Sites (1)

Queen Alexandra Hospital

Portsmouth, Hampshire, PO6 3LY, United Kingdom

Location

MeSH Terms

Conditions

Churg-Strauss Syndrome

Condition Hierarchy (Ancestors)

Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis; Systemic Vasculitis; Vasculitis; Vascular Diseases; Cardiovascular Diseases; Granuloma; Lymphoproliferative Disorders; Lymphatic Diseases; Hemic and Lymphatic Diseases; Skin Diseases, Vascular; Skin Diseases; Skin and Connective Tissue Diseases; Autoimmune Diseases; Immune System Diseases

Study Officials

• Anoop J Chauhan, PhD FRCP

  Portsmouth Hospitals NHS Trust

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 26, 2016
• First Posted: January 30, 2017
• Study Start: August 10, 2016
• Primary Completion: January 31, 2017
• Study Completion: January 31, 2017
• Last Updated: April 7, 2023

Record last verified: 2023-04

Locations

GB (1)