NCT00315380|RecruitingDMC
Longitudinal Study for Eosinophilic Granulomatosis With Polyangiitis
Longitudinal Protocol for Eosinophilic Granulomatosis With Polyangiitis
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Longitudinal Protocol for Eosinophilic Granulomatosis With Polyangiitis
Sponsor study identifier
observational
700
5 countries
15
Study Start
April 2006
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
December 2028
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
December 2028
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare immune system disorder that causes asthma, an excessive number of eosinophils (a type of white blood cell) in the blood, and the inflammation of blood vessels, or vasculitis. In order to properly treat EGPA, it is critical that the level of disease activity can be determined over the course of the disease. The purpose of this study is to determine new biological markers, or biomarkers, that may be used to assess the severity of this disease in people with EGPA.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
December 2028
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
April 2006
Date type not reportedThis date has not been verified as actual or estimated.
April 14, 2006
Actual (reported)April 18, 2006
Actual (reported)December 2028
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
December 2028
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Discover biomarkers in EGPA capable of measuring disease activity and response to treatment
Study completion
Measure the predictive value of biomarkers for clinical outcome in EGPA
Study completion.
Individuals with eosinophilic granulomatosis with polyangiitis (Churg-Strauss). Enrollment will be sequential and participants will have disease in various stages and of different duration.
University of California San Diego
San Diego, California, 92122, United States
National Jewish Health
Denver, Colorado, 80206, United States
Brigham and Women's Hospital
Boston, Massachusetts, 02215, United States
Mayo Clinic
Rochester, Minnesota, 55905, United States
Heeringa P, Schreiber A, Falk RJ, Jennette JC. Pathogenesis of pulmonary vasculitis. Semin Respir Crit Care Med. 2004 Oct;25(5):465-74. doi: 10.1055/s-2004-836140.
Radice A, Sinico RA. Antineutrophil cytoplasmic antibodies (ANCA). Autoimmunity. 2005 Feb;38(1):93-103. doi: 10.1080/08916930400022673.
Said G, Lacroix C. Primary and secondary vasculitic neuropathy. J Neurol. 2005 Jun;252(6):633-41. doi: 10.1007/s00415-005-0833-9. Epub 2005 Apr 5.
Blood (serum and plasma), urine, and DNA
Peter A. Merkel, MD, MPH
University of Pennsylvania
First Submitted
April 14, 2006
First Posted
April 18, 2006
Study Start
April 2006
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
December 2028
EstimatedMepolizumab Long-term Study to Assess Real World Safety and Effectiveness of Eosinophilic Granulomatosis With Polyangiitis (EGPA) in Japan
Contact the study team to confirm eligibility.
Cleveland Clinic Foundation
Cleveland, Ohio, 44195, United States
University of Pennsylvania
Philadelphia, Pennsylvania, 19104, United States
University of Pittsburgh
Pittsburgh, Pennsylvania, 15260, United States
University of Utah
Salt Lake City, Utah, 84112, United States
St. Joseph's Healthcare
Hamilton, Ontario, Canada
Mount Sinai Hospital
Toronto, Ontario, Canada
medius KLINIK KIRCHHEIM
Kirchheim unter Teck, 73230, Germany
AOU Meyer IRCCS
Florence, Italy
Cambridge University Hospitals Nhs Foundation Trust
Cambridge, United Kingdom
Imperial College Healthcare NHS Trust/ Imperial College London
London, W12 0NN, United Kingdom
Guy'S and St Thomas' Nhs Foundation Trust
London, United Kingdom
Doubelt I, Cuthbertson D, Carette S, Khalidi NA, Koening CL, Langford C, McAlear CA, Moreland LW, Monach P, Seo P, Specks U, Warrington KJ, Merkel PA, Pagnoux C. Vitamin D status in ANCA-associated vasculitis. Rheumatol Adv Pract. 2023 Feb 10;7(1):rkad021. doi: 10.1093/rap/rkad021. eCollection 2023.
Doubelt I, Springer JM, Kermani TA, Sreih AG, Burroughs C, Cuthbertson D, Carette S, Khalidi NA, Koening CL, Langford C, McAlear CA, Moreland LW, Monach PA, Shaw DG, Seo P, Specks U, Warrington KJ, Young K, Merkel PA, Pagnoux C. Self-Reported Data and Physician-Reported Data in Patients With Eosinophilic Granulomatosis With Polyangiitis: Comparative Analysis. Interact J Med Res. 2022 May 25;11(1):e27273. doi: 10.2196/27273.
Planned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
December 2028
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Last Updated
August 28, 2026
Record last verified: 2026-08
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