NCT03035123

Brief Summary

The EduStra-HF study will examine the impact of an intensive therapeutic education on patients discharged from hospital after an episode of acute heart failure (HF). Patients will be randomized into two groups: one will receive "usual care" monitoring and one will receive a specific educational monitoring programme for 1 year. All patients will meet with a specialized therapeutic education nurse before discharge. The effect of the intensive education on HF rehospitalization and quality of life will be examined.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
318

participants targeted

Target at P75+ for not_applicable heart-failure

Timeline
Completed

Started Apr 2017

Longer than P75 for not_applicable heart-failure

Geographic Reach
1 country

6 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

December 5, 2016

Completed
2 months until next milestone

First Posted

Study publicly available on registry

January 27, 2017

Completed
2 months until next milestone

Study Start

First participant enrolled

April 1, 2017

Completed
6.8 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 30, 2023

Completed
1 year until next milestone

Study Completion

Last participant's last visit for all outcomes

December 30, 2024

Completed
Last Updated

April 3, 2025

Status Verified

March 1, 2025

Enrollment Period

6.8 years

First QC Date

December 5, 2016

Last Update Submit

March 31, 2025

Conditions

Keywords

Heart FailureTherapeutic educationQuality of life

Outcome Measures

Primary Outcomes (1)

  • Number of rehospitalizations for acute heart failure (HF) in both groups of patients

    1 year

Secondary Outcomes (7)

  • Patients knowledge about the illness

    1 year

  • Global quality of life

    1 year

  • Quality of life linked to Heart Failure

    1 year

  • Length of stay for HF and all-cause hospitalizations

    1 year of follow-up

  • Hospitalization rate for cardiovascular diseases except HF

    1 year of follow-up

  • +2 more secondary outcomes

Other Outcomes (1)

  • Cost effectiveness of the intervention

    During 1 year of follow-up

Study Arms (2)

"Usual care"

NO INTERVENTION

Patients will attend an appointment with the therapeutic education nurse before discharge, after which they will have no further contact with the education team. The Research team members will telephone the patient three times during the year (after 2, 6 and 12 months) to collect data on HF treatments, blood tests results, health-related events and hospitalizations.

Interventional

EXPERIMENTAL

Before discharge, patients will attend an appointment with a nurse trained in therapeutic education, in which the nurse will evaluate the overall knowledge and the skills of the patient about HF. The nurse will then define specific educational objectives with the patient, based on the patient's medical history, state of disease, comorbidities, alarm signs, fears and knowledge. Each patient will receive six telephone calls and two home-visits during the 1 year of follow-up. Each contact between the nurse and the patient will be dedicated to HF education. The patient will also receive regular short text messages containing health advice and appointment reminders. To help the patient regain his/her autonomy, intervals between education sessions will be progressively longer.

Behavioral: Therapeutic education

Interventions

Interventional arm

Interventional

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Adult patient with acute HF
  • Affiliated to the French Social Security system
  • Accepting the principle of telephone monitoring
  • Accepting home visits from a study nurse
  • Possession of a mobile phone

You may not qualify if:

  • Psychosocial:
  • Refusal to accept the study design
  • Patient under guardianship
  • Monitoring obstacle: language, cognitive deficiency, itinerant lifestyle, regular travel, institutionalization
  • Inability to sign the consent form or to complete questionnaires
  • Medical:
  • Active cancer
  • Severe psychiatric or neurological disorder
  • Complicated acute myocardial infarction
  • Significant valvular diseases requiring surgery
  • Hypertrophic obstructive cardiomyopathy
  • Planned heart transplant
  • Cardiac surgery in the previous 3 months
  • Enrollment in another clinical trial
  • Medical or surgical procedure which might interfere with monitoring

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (6)

Clinique Ambroise Paré

Neuilly-sur-Seine, 92200, France

Location

Clinique du Mont Louis

Paris, 75011, France

Location

Hopital AP-HP Saint-Antoine

Paris, 75012, France

Location

Institut Mutualiste Montsouris

Paris, 75014, France

Location

Centre Cardiologique du Nord

Saint-Denis, 93200, France

Location

Centre Hospitalier André Mignot

Versailles, 78000, France

Location

Related Publications (1)

  • Jullien S, Lang S, Gerard M, Soulat-Dufour L, Brito E, Ocokoljic E, Laperche T, Georges JL, Diakov C, Belliard O, Larrazet F, Bataille S, Assyag P, Cohen A; EduStra-HF investigators. Intensive therapeutic education strategy for patients with acute heart failure (EduStra-HF): Design of a randomized controlled trial. Arch Cardiovasc Dis. 2024 Oct;117(10):561-568. doi: 10.1016/j.acvd.2024.04.006. Epub 2024 Jul 4.

MeSH Terms

Conditions

Heart Failure

Condition Hierarchy (Ancestors)

Heart DiseasesCardiovascular Diseases

Study Officials

  • Ariel Cohen, MD PhD

    Hôpital Saint-Antoine

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
SUPPORTIVE CARE
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Head of the cardiology department

Study Record Dates

First Submitted

December 5, 2016

First Posted

January 27, 2017

Study Start

April 1, 2017

Primary Completion

December 30, 2023

Study Completion

December 30, 2024

Last Updated

April 3, 2025

Record last verified: 2025-03

Locations