Fever Observational Study
An Observational Study of the Epidemiology of Fever Due to Infection in Critically Ill Children Following an Unplanned Admission to a Paediatric Intensive Care Unit
1 other identifier
observational
3,960
1 country
1
Brief Summary
To inform the feasibility of conducting a study to test different temperature thresholds at which clinicians deliver interventions to reduce fever (i.e. antipyretic interventions) in critically ill children with fever due to infection.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Feb 2017
Shorter than P25 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
January 13, 2017
CompletedFirst Posted
Study publicly available on registry
January 23, 2017
CompletedStudy Start
First participant enrolled
February 1, 2017
CompletedPrimary Completion
Last participant's last visit for primary outcome
July 1, 2017
CompletedStudy Completion
Last participant's last visit for all outcomes
August 1, 2017
CompletedJanuary 23, 2017
January 1, 2017
5 months
January 13, 2017
January 19, 2017
Conditions
Outcome Measures
Primary Outcomes (7)
To determine the number of patients who meet the eligibility criteria for a proposed definitive trial.
Baseline
Temperature thresholds currently employed in at least 20 paediatric intensive care units (PICU) in the UK
First 5 calender days
Length of ventilation - mean (standard deviation)
Through study completion, an average of 2 days
Length of PICU stay - mean (standard deviation)
Through study completion, an average of 2 days
PICU mortality - number (percentage)
Through study completion, an average of 2 days
Hospital mortality - number (percentage)
Through study completion, an average of 2 days
Days of organ specific support - mean (standard deviation)
Through study completion, an average of 2 days
Eligibility Criteria
All unplanned admissions to a PICU
You may qualify if:
- unplanned PICU admission referral requiring PICU admission to a participating unit
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Intensive Care National Audit and Research Centre
London, WC1V 6AZ, United Kingdom
Related Publications (2)
Deja E, Peters MJ, Khan I, Mouncey PR, Agbeko R, Fenn B, Watkins J, Ramnarayan P, Tibby SM, Thorburn K, Tume LN, Rowan KM, Woolfall K. Establishing and augmenting views on the acceptability of a paediatric critical care randomised controlled trial (the FEVER trial): a mixed methods study. BMJ Open. 2021 Mar 10;11(3):e041952. doi: 10.1136/bmjopen-2020-041952.
PMID: 33692177DERIVEDPeters MJ, Khan I, Woolfall K, Deja E, Mouncey PR, Wulff J, Mason A, Agbeko R, Draper ES, Fenn B, Gould DW, Koelewyn A, Klein N, Mackerness C, Martin S, O'Neill L, Ramnarayan P, Tibby S, Tume L, Watkins J, Thorburn K, Wellman P, Harrison DA, Rowan KM. Different temperature thresholds for antipyretic intervention in critically ill children with fever due to infection: the FEVER feasibility RCT. Health Technol Assess. 2019 Feb;23(5):1-148. doi: 10.3310/hta23050.
PMID: 30793698DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Mark Peters, MBChB, PhD
Institute of Child Health
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Target Duration
- 30 Days
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
January 13, 2017
First Posted
January 23, 2017
Study Start
February 1, 2017
Primary Completion
July 1, 2017
Study Completion
August 1, 2017
Last Updated
January 23, 2017
Record last verified: 2017-01