Opioids Titration Study in Advanced Cancer Patients in Hong Kong

NCT03024515 | Completed

• 1 other identifier: SYM012
• Study Type: interventional
• Target: 2
• Locations: 1 country
• Sites: 1

Brief Summary

Pain is a common symptom that is experienced by patients with advanced cancer. Whilst mild pain can usually be controlled with simple analgesics, more severe pain may require initiation of opioid analgesics. The World Health Organization (WHO) has developed a specific guideline for titration of analgesics. Known as the WHO Pain Ladder, patients who have severe pain despite non-opioid and weak opioid analgesics are advised to step up to level 3 - "Strong Opioids". Morphine is the most common opioid strong analgesic prescribed in Hong Kong. To the best of our knowledge, there is no formal opioid pain control guideline developed for cancer patients in Hong Kong. The prescription practices of various physicians who treat advance cancer patients, including oncologists and palliative care physicians have never been audited or standardized. Furthermore, there are inherent issues with the administration of oral morphine. Currently, only one fixed concentration is available in a liquid formulation. Patients are known to have difficulties in receiving the appropriate dose. Accurate measurement of the volume required is extremely difficult, and many a times patients will report to have spilled the oral morphine during decanting, or will report that they have not been taking adequate doses because they are worried that they will decant too much into a spoon or syringe and overdose themselves. Oxycodone is a semisynthetic strong opioid analgesic, which has recently been introduced to Hong Kong. It is formulated as a capsule, and again, 2 preparations (sustained-release (Oxycontin) and immediate release (Oxycodone IR)) are available. Inherent advantages include ease of administration; different groups have previously reported less adverse effects and better treatment compliance. However, to date, there has been no prospective 'head-to-head' comparison have ever been carried out comparing this with the traditional, well-accepted methods. The purpose of this study is to assess whether or not the use of Oxycontin and Oxycodone IR may be superior to traditional medication choices and schedules in terms of time required for onset of pain control, the side effect profile, patients' tolerability and compliance to treatment. Interestingly, through this randomized open-label prospective study, we also aim to capture information on current opioid prescription practices by clinicians who manage patients with advanced cancers, which will be useful for us to consider the establishment of territory-wide treatment guidelines at a later juncture.

Conditions

Pain Control

Outcome Measures

Primary Outcomes (1)

• Time to stabilization of pain control during titration phase

  1 year

Secondary Outcomes (6)

• Time of analgesic onset

  1 year

• Number of breakthrough medications required during the titration phase

  1 year

• Quality of Life assessments using the EORTC QLQ-C15-PAL instrument

  1 year

• A descriptive assessment of opioids prescription practice amongst practicing oncologists in Hong Kong

  1 year

• Safety profile and adverse events

  1 year

Study Arms (2)

Standard Practice Arm

EXPERIMENTAL

Standard Practice Arm with opioids titration of physicians' choice

Drug: opioids titration

Structured Tritration Arm

EXPERIMENTAL

Structured titration method with predefined titration steps with the use of oxycodone immediate-release and oxycodone sustained-release preparations.

Drug: predefined titration steps

Interventions

opioids titration DRUG

Standard Practice Arm

Standard Practice Arm

predefined titration steps DRUG

comprising of oxycodone immediate release (OXYNORM) and oxycodone sustained release (OXYCONTIN) in pre-defined doses and frequencies

Structured Tritration Arm

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Adult patient with moderate to severe cancer pain, and:
• Opioid naïve patients, who were administrated NSAIDs or weak opioids and currently with poor pain control, intend to be treated with strong opioids
• For the patients who need long term administration of hormone or targeting therapy or bisphosphonates therapy, the treatments will maintain from 3 days prior to randomization to end of the study as much as possible.
• For patients who need radiotherapy or chemotherapy, these therapies should be conducted during maintaining phase and completed as assuring as possible before last follow-up.

You may not qualify if:

• The pure neuropathic pain or unexplained pain, pain that only occurs during moving; Acute pain
• The patients who are not applicable for oral administration
• Any disease that may lead to respiration inhibition of the subjects
• Monoamine oxidase inhibitor (MAOI) was administrated one week before randomization;
• There are abnormal results, with obvious clinical significance, from lab testing, such as the creatinine is ≥2-fold of upper limit of normal value, or ALT or AST is ≥2-fold of upper limit of normal value, or liver function is Child C grade;
• There are potential gastrointestinal diseases or the risk of surgical operation, which may lead to gastrointestinal stenosis, blind loop or gastrointestinal obstruction;
• Patients have been exposed to prolonged-release oxycodone tablets or other strong opioids drugs before study.

Sponsors & Collaborators

• Chinese University of Hong Kong: lead

Study Sites (1)

Department of Clinical Oncology, Prince of Wales Hospital

Hong Kong, Hong Kong

Location

MeSH Terms

Conditions

Agnosia

Condition Hierarchy (Ancestors)

Perceptual Disorders; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor (Clinical)

Study Record Dates

• First Submitted: November 23, 2016
• First Posted: January 19, 2017
• Study Start: August 23, 2018
• Primary Completion: December 7, 2020
• Study Completion: December 7, 2020
• Last Updated: July 28, 2021

Record last verified: 2021-07

Data Sharing

• IPD Sharing: Will not share

Locations

HK (1)