NCT03023332

Brief Summary

How do varying levels of participation in selecting self-management interventions (ranging from no input into the selection to selection based on need or preference) affect health risks and physical and mental health over time in family caregivers of persons with bipolar disorder? Caregivers will be randomized to: 1) a control group (no intervention); 2) education (usual care); 3) self-management intervention based on need (SM-need); or 4) self-management intervention of their preference (SM-preference).

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
310

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Jun 2017

Longer than P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

January 13, 2017

Completed
5 days until next milestone

First Posted

Study publicly available on registry

January 18, 2017

Completed
5 months until next milestone

Study Start

First participant enrolled

June 12, 2017

Completed
4.1 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 30, 2021

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

June 30, 2021

Completed
2.4 years until next milestone

Results Posted

Study results publicly available

November 15, 2023

Completed
Last Updated

November 15, 2023

Status Verified

November 1, 2023

Enrollment Period

4.1 years

First QC Date

January 13, 2017

Results QC Date

August 25, 2023

Last Update Submit

November 13, 2023

Conditions

Keywords

CaregiverBiofeedbackResourcefulnessSelf-Management

Outcome Measures

Primary Outcomes (2)

  • Change in Caregiver Health - Health Risks

    Health risks were measured using the Change in Health Risk Behavior Scale. The scale consists of 9 items measured on a 3-point scale, Scores range 9-27; higher score indicates greater risk

    12 months

  • Change in Global Health - PROMIS (Patient Reported Outcomes Measurement Information System)

    Change in Global Health - PROMIS (Patient Reported Outcomes Measurement Information System) scale. 5 items - physical health; 5 items - mental health; 5-point scale; Scores range 0-40; higher scores indicate better health.

    12 months

Secondary Outcomes (3)

  • Change in Bipolar Knowledge Assessment Scale

    12 months

  • Change in Heart Rate Variability

    12 months

  • Change in Resourcefulness

    12 months

Study Arms (4)

Self-management need

EXPERIMENTAL

SM-need (i.e. need for bipolar education or resourcefulness training or HRV-focused biofeedback training or no need for any)

Behavioral: Resourcefulness TrainingBehavioral: Biofeedback trainingBehavioral: Bipolar Education

Self-management preference

EXPERIMENTAL

SM-preference (i.e. preference for bipolar education or resourcefulness training or HRV-focused biofeedback training or no intervention)

Behavioral: Resourcefulness TrainingBehavioral: Biofeedback trainingBehavioral: Bipolar Education

Control

NO INTERVENTION

No intervention or treatment

Usual care

ACTIVE COMPARATOR

Bipolar education

Behavioral: Bipolar Education

Interventions

A cognitive-behavioral intervention delivered through iPad technology that consists of teaching and reinforcing personal (self-help) and social (help-seeking) resourcefulness skills.

Self-management needSelf-management preference

Use of a heart-rate variability (HRV) tracking device to enable one to learn to alter physiology to improve health. Devices are used to measure physiological activity, e.g., breathing and heart function, and provide rapid, accurate "feedback" to the user, thereby enabling desired physiological changes that can endure over time without continued use of the device and continue to influence behavior.

Self-management needSelf-management preference

An educational program designed to teach family caregivers of about the types, causes, symptoms, episodes, warning signs, and treatments for individuals with bipolar disorder, as well as available resources for assisting a family member with bipolar disorder. The content to be presented within an audiovisual format using iPad technology follows the recommendations and guidelines developed through research and by the Depression and Bipolar Support Alliance and the National Institute of Mental Health.

Self-management needSelf-management preferenceUsual care

Eligibility Criteria

Age18 Years - 120 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • English-speaking
  • At least 18 years old
  • Have a family member with bipolar disorder
  • Have cared/supported them for at least the last 6 months in the last year
  • Be capable of performing the informed consent and participate in interventions

You may not qualify if:

  • Does not have family member with bipolar disorder
  • Has not cared for family member for at least 6 months in the last year
  • Knowledge of another family member in the same household enrolled in the study
  • Is pregnant
  • Has a pacemaker
  • Lives outside of the study area (Cuyahoga, Lake, Geauga, Portage, Summit, Medina, and Lorain counties)

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

CWRU School of Nursing

Cleveland, Ohio, 44106, United States

Location

Related Publications (1)

  • Zauszniewski JA, Burant CJ, Juratovac E, Jeanblanc A, Sweetko JS, Larsen C, Almutairi R, She HY, DiFranco E, Colon-Zimmerman K, Sajatovic M. Acquiring Resourcefulness Skills: Formal Versus Informal Training. West J Nurs Res. 2025 Jan;47(1):5-14. doi: 10.1177/01939459241296613. Epub 2024 Nov 13.

Results Point of Contact

Title
Jaclene Zauszniewski, PhD
Organization
Case Western Reserve University

Study Officials

  • Jaclene Zauszniewski, PhD

    Case Western Reserve University - Frances Payne Bolton School of Nursing

    PRINCIPAL INVESTIGATOR

Publication Agreements

PI is Sponsor Employee
No
Restrictive Agreement
No

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
CARE PROVIDER, OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principal Investigator

Study Record Dates

First Submitted

January 13, 2017

First Posted

January 18, 2017

Study Start

June 12, 2017

Primary Completion

June 30, 2021

Study Completion

June 30, 2021

Last Updated

November 15, 2023

Results First Posted

November 15, 2023

Record last verified: 2023-11

Data Sharing

IPD Sharing
Will not share

Locations