NCT03023215

Brief Summary

The goal of this behavioral research study is to learn if taking part in guided relaxation programs helps to reduce anxiety and pain during stereotactic breast biopsy. The study will also examine whether the guided relaxation programs change brain activity, heart rate, and blood pressure.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
84

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started Oct 2012

Longer than P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

October 26, 2012

Completed
4.2 years until next milestone

First Submitted

Initial submission to the registry

January 13, 2017

Completed
5 days until next milestone

First Posted

Study publicly available on registry

January 18, 2017

Completed
5.6 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 10, 2022

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

August 10, 2022

Completed
Last Updated

September 7, 2023

Status Verified

September 1, 2023

Enrollment Period

9.8 years

First QC Date

January 13, 2017

Last Update Submit

September 5, 2023

Conditions

Keywords

MeditationBreast BiopsyStereotactic Breast BiopsySBBGuided meditationFocused breathingElectroencephalogramEEGHeart rateHRQuestionnairesSurveys

Outcome Measures

Primary Outcomes (1)

  • Participation and Completion Rate of Incorporating a Guided Meditation Program in Participants Undergoing Stereotactic Breast Biopsy (SBB)

    Trial considered successful if over 50% of eligible patients participate and at least 80% of the consented patients complete the sessions and all the measures for the study.

    1 day

Secondary Outcomes (1)

  • Effect of GM Compared to Focused Breathing (FB) and Standard Care (SC) Control Groups on Self-Reported Anxiety in Participants Undergoing SBB

    3-5 minute intervals throughout the SBB procedure

Study Arms (3)

Guided Meditation Group (GM)

EXPERIMENTAL

Participants guided through 10 minutes of intervention by a mind-body specialist who will follow a standardized script prior to stereotactic breast biopsy (SBB). Mind-body specialist will also accompany participant during SBB to continue intervention. Electroencephalogram (EEG) activity and heart rate (HR) recorded at baseline, for 10 minutes prior to the SBB, throughout the SBB, and immediately following SBB. Self-report measures (anxiety and pain) assessed at baseline, immediately before, during, and after the SBB.

Procedure: MeditationProcedure: ElectroencephalogramBehavioral: QuestionnairesProcedure: Heart Rate

Focused Breathing Group (FB)

ACTIVE COMPARATOR

Participants guided through 10 minutes of intervention by a mind-body specialist who will follow a standardized script prior to stereotactic breast biopsy (SBB). Mind-body specialist will also accompany participant during SBB to continue intervention. Electroencephalogram (EEG) activity and heart rate (HR) recorded at baseline, for 10 minutes prior to the SBB, throughout the SBB, and immediately following SBB. Self-report measures (anxiety and pain) assessed at baseline, immediately before, during, and after the SBB..

Procedure: MeditationProcedure: ElectroencephalogramBehavioral: QuestionnairesProcedure: Heart Rate

Standard of Care Group (SC)

ACTIVE COMPARATOR

Participants listen to a 10 minute neutral-content audio clip from National Public Radio prior to stereotactic breast biopsy (SBB). Electroencephalogram (EEG) activity and heart rate (HR) recorded at baseline, for 10 minutes prior to the SBB, throughout the SBB, and immediately following SBB. Self-report measures (anxiety and pain) assessed at baseline, immediately before, during, and after the SBB.

Procedure: ElectroencephalogramBehavioral: QuestionnairesProcedure: Heart Rate

Interventions

MeditationPROCEDURE

Participants guided through 10 minutes of intervention by a mind-body specialist who will follow a standardized script prior to stereotactic breast biopsy (SBB). Mind-body specialist will also accompany participant during SBB to continue intervention.

Focused Breathing Group (FB)Guided Meditation Group (GM)

Electroencephalogram (EEG) activity recorded at baseline, for 10 minutes prior to the SBB, throughout the SBB, and immediately following SBB.

Also known as: EEG
Focused Breathing Group (FB)Guided Meditation Group (GM)Standard of Care Group (SC)
QuestionnairesBEHAVIORAL

Self-report measures (anxiety and pain) assessed at baseline, immediately before, during, and after the SBB.

Also known as: Surveys
Focused Breathing Group (FB)Guided Meditation Group (GM)Standard of Care Group (SC)
Heart RatePROCEDURE

Heart rate (HR) recorded at baseline, for 10 minutes prior to the SBB, throughout the SBB, and immediately following SBB.

Also known as: HR
Focused Breathing Group (FB)Guided Meditation Group (GM)Standard of Care Group (SC)

Eligibility Criteria

Age18 Years+
Sexfemale
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Women must have the ability to understand and read English, sign a written informed consent, and be willing to follow protocol requirements.
  • Women must be right hand dominant.
  • Women must be 18 years or older.

You may not qualify if:

  • Women who have a documented diagnosis of a formal thought disorder (e.g., schizophrenia) will be excluded from the study.
  • Women with a score of 3 or below on the Six-Item Cognitive Screener.
  • Women who plan to take benzodiazepine (e.g, alprazolam, diazepam, clonazepam, lorazepam) or beta-blocker (e.g., propranolol, atenolol) on the day of their SBB.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University of Texas MD Anderson Cancer Center

Houston, Texas, 77030, United States

Location

Related Links

MeSH Terms

Interventions

MeditationSurveys and QuestionnairesHeart Rate

Intervention Hierarchy (Ancestors)

Mind-Body TherapiesComplementary TherapiesTherapeuticsSpiritual TherapiesRelaxation TherapyBehavior TherapyPsychotherapyBehavioral Disciplines and ActivitiesData CollectionEpidemiologic MethodsInvestigative TechniquesHealth Care Evaluation MechanismsQuality of Health CareHealth Care Quality, Access, and EvaluationPublic HealthEnvironment and Public HealthVital SignsPhysical ExaminationDiagnostic Techniques and ProceduresDiagnosisHemodynamicsCardiovascular Physiological PhenomenaCirculatory and Respiratory Physiological Phenomena

Study Officials

  • Lorenzo Cohen, PHD

    M.D. Anderson Cancer Center

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
PARTICIPANT
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

January 13, 2017

First Posted

January 18, 2017

Study Start

October 26, 2012

Primary Completion

August 10, 2022

Study Completion

August 10, 2022

Last Updated

September 7, 2023

Record last verified: 2023-09

Locations