NCT03021876|UnknownPhase 2/3DMC
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Sponsor study identifier
interventional
80
1 country
1
Study Start
April 2016
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
April 2018
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
April 2018
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
L-carnitine is synthesized from lysine and methionine. Postmortem concentrations of carnitine in liver, muscle, heart, kidney, and brain averaged only one-fourth to one-third those in corresponding tissues of eight normally nourished non-hepatic patients who died after an acute illness of a 1-3-day duration. In the recent years, it has been reported that sirtuin 3 (SIRT3) is protective against acute kidney injury (AKI) and suggest that enhancing SIRT3 to improve mitochondrial dynamics has potential as a strategy for improving outcomes of renal injury. In the current study, it is the first clinical interventional research whether L-carnitine corrects ammonia metabolism associated with liver injury in hepatectomized patients.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
April 2018
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
March 12, 2016
Actual (reported)April 2016
Date type not reportedThis date has not been verified as actual or estimated.
January 16, 2017
Actual (reported)April 2018
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
April 2018
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
postoperative ammonia levels
change from preoperative baseline at postoperative day 1 and day3
3 points; preoperative baseline, postoperative day 1, and day3
length of hospitalization after liver resection
up to 24 weeks
usual intake prior to liver surgery
treatment with oral L-carnitine, 1500 mg/body per day for 2 weeks prior to liver surgery
treatment with oral L-carnitine, 1500 mg/body per day
Contact the study team to confirm eligibility.
Kochi Health Sciences Center
Kochi, Kochi, 781-0111, Japan
Okabayashi T, Sui K, Mastumoto T, Iwata J, Morita S, Iiyama T, Shimada Y. l-Carnitine Improves Postoperative Liver Function in Hepatectomized Patients. JPEN J Parenter Enteral Nutr. 2020 Jul;44(5):823-830. doi: 10.1002/jpen.1720. Epub 2019 Oct 9.
First Submitted
March 12, 2016
First Posted
January 16, 2017
Study Start
April 2016
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
April 2018
Estimated (date passed)Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
April 2018
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Last Updated
January 16, 2017
Record last verified: 2017-01
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Source: ClinicalTrials.gov.
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