Exploring Time-efficient Strategies to Improve Fitness for Surgery in Older Adults

NCT03019146 | Unknown

• 1 other identifier: A12092016
• Study Type: interventional
• Target: 48
• Locations: 1 country
• Sites: 1

Brief Summary

The incidence of conditions requiring surgical intervention increases with age, however there is a reported decline in the rates of elective surgical procedures in those over 65. This is associated with older patients being described as "less fit" and more at risk of postoperative complications, leading to decreased provision of surgical care to those at need. Exercise interventions have the potential to reverse some of the decline in cardiovascular fitness associated with aging and improve the elderly's' "fitness for surgery" and potentially allow increased access to surgical care for those most in need of it.

Conditions

Perioperative Hypertension; Hypertension

Keywords

Prehabilitation

Outcome Measures

Primary Outcomes (1)

• Change in resting systolic blood pressure

  Measured in seated position using oscillometry, mean value of 3 recordings, measured according to British Society of Hypertension Guidelines 2013.

  6 weeks

Secondary Outcomes (20)

• Change in resting diastolic blood pressure

  6 weeks

• Ambulatory blood pressure

  6 weeks

• V02 Peak

  6 weeks

• Anaerobic threshold

  6 weeks

• Body fat percentage

  6 weeks

Study Arms (4)

High Intensity Interval Training (HIIT)

EXPERIMENTAL

3 x 15 minute sessions per week for 6 weeks. Sessions include 5x intervals of cycling at 110% of Wmax derived from CPET, interspersed with 90s rest periods of unloaded cycling.

Other: HIIT

Isometric Handgrip (HOLD)

EXPERIMENTAL

3x 15 minute sessions per week for 6 weeks Sessions include 4x intervals of 2minutes isometric handgrip contraction of dominant arm at 30% Maximal voluntary contraction, interspersed with 2minute rest periods

Other: HOLD

Remote Ischaemic Preconditioning (HUG)

EXPERIMENTAL

3x 15 minute sessions per week for 6 weeks. Sessions include 3x intervals of 3 minutes of arm ischaemia (blood pressure cuff inflated to 200mmHg on dominant arm) interspersed with 3 minute rest periods.

Other: HUG

Control

NO INTERVENTION

No intervention

Interventions

HIIT OTHER

Also known as: High intensity Interval training

High Intensity Interval Training (HIIT)

HOLD OTHER

Also known as: Isometric exercise, Isometric handgrip

Isometric Handgrip (HOLD)

HUG OTHER

Also known as: Remote ischaemic preconditioning, Ischaemic preconditioning

Remote Ischaemic Preconditioning (HUG)

Eligibility Criteria

• Age: 65 Years - 85 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Older Adult (65+)

You may qualify if:

• Healthy volunteer aged 65-85

You may not qualify if:

• Current participation in a formal exercise regime
• A BMI \< 18 or \> 32 kg·m2
• Active cardiovascular disease:
• uncontrolled hypertension (BP \> 160/100),
• angina,
• heart failure (class III/IV),
• Significant arrhythmia,
• right to left cardiac shunt,
• recent cardiac event
• Taking beta-adrenergic blocking agents,
• Cerebrovascular disease:
• previous stroke,
• aneurysm (large vessel or intracranial)
• epilepsy
• Respiratory disease including:

Sponsors & Collaborators

• University of Nottingham: lead
• The Royal College of Surgeons of England: collaborator
• The Dunhill Medical Trust: collaborator

Study Sites (1)

University Of Nottingham

Derby, DE22 3NE, United Kingdom

Location

Related Publications (18)

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  PMID: 23665968 BACKGROUND

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  PMID: 11699041 BACKGROUND

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  PMID: 19196912 BACKGROUND

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  PMID: 24627443 BACKGROUND

Related Links

• Office for National Statistics; Population Ageing in the United Kingdom, its Constituent Countries and the European Union

MeSH Terms

Conditions

Hypertension

Interventions

High-Intensity Interval Training; Exercise; Ischemic Preconditioning

Condition Hierarchy (Ancestors)

Vascular Diseases; Cardiovascular Diseases

Intervention Hierarchy (Ancestors)

Physical Conditioning, Human; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena; Therapeutics; Investigative Techniques

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 4, 2017
• First Posted: January 12, 2017
• Study Start: January 4, 2017
• Primary Completion: April 25, 2019
• Study Completion: August 1, 2019
• Last Updated: May 7, 2019

Record last verified: 2019-05

Data Sharing

• IPD Sharing: Will not share

Locations

GB (1)