Hypertension Management in Young Adults Personalised by Echocardiography and Clinical Outcome.

NCT03762499 | Recruiting DMC

• 1 other identifier: 247606
• Study Type: interventional
• Target: 750
• Locations: 1 country
• Sites: 1

Brief Summary

HyperEcho is a multi-centre longitudinal observational study, to investigate whether baseline transthoracic echocardiography along with routine data collected in the hypertension clinic can guide clinicians to better manage, and improve risk stratification for cardiovascular disease in young adults with hypertension. Participants are characterised as young adult patients aged between 18 to 40 years old and referred to the hypertension clinic to manage their blood pressure. The study visit will be carried out during the planned routine visit of the participants to the hypertension clinics of NHS trusts within England. Routine data will be collected by the assigned nurse for the hypertension clinic as part of the clinical service, and research participation will not affect the clinical progress of the participant. The additional research component to the clinic will be asking the participants for their consent to undergo a research echocardiography scan if it has not been a part of their clinical assessment. Participants will also be asked to consent to the use of their data that has been collected in the hypertension clinic, such as; referral letters, medical history, 24-hour blood pressure monitoring report, ECG, blood samples, body fat composition, and dietary questionnaire. In addition to this, participants will be asked to consent to further review of their data and medical notes during their follow up visits (up to 10 years).

Conditions

Hypertension

Keywords

Young adults; Echocardiography

Outcome Measures

Primary Outcomes (1)

• Identification of patient clusters based on echocardiographic and clinical findings

  Number of hypertension patient clusters based on echocardiographic and clinical findings

  Obtained at the first clinical visit

Study Arms (2)

Prospective participants

ACTIVE COMPARATOR

250 participants will be recruited prospectively during the hypertension clinic, where a full set of data will be collected from each participant as part of their standard hypertension clinical service. An additional echocardiography scan will be performed for this cohort by the study team, if the scan has not been performed as a part of the clinical care service

Diagnostic Test: Echocardiography scan

Retrospective participants

NO INTERVENTION

500 participants will be recruited retrospectively, and no additional echocardiography scan will be required for them.

Interventions

Echocardiography scan DIAGNOSTIC_TEST

Non-invasive ultrasound imaging of the heart.

Prospective participants

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Participant is willing and able to give informed consent for participation in the study.
• Male or Female, aged 18 - 40 years (at the time of their appointment at the hypertension clinic).
• Referred for a Hypertension Clinic in England.

You may not qualify if:

• Unable or unwilling to give valid consent for participation in the study.

Sponsors & Collaborators

• University of Oxford: lead

Study Sites (1)

Cardiovascular Clinical Research Facility

Oxford, OX3 9DU, United Kingdom

RECRUITING

MeSH Terms

Conditions

Hypertension

Condition Hierarchy (Ancestors)

Vascular Diseases; Cardiovascular Diseases

Central Study Contacts

Maryam Alsharqi

CONTACT

+44(0)1865 572832; maryam.alsharqi@cardiov.ox.ac.uk

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: QUADRUPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: DIAGNOSTIC
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 6, 2018
• First Posted: December 3, 2018
• Study Start: October 2, 2018
• Primary Completion (Estimated): August 1, 2028
• Study Completion (Estimated): August 1, 2038
• Last Updated: April 29, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will share

Locations

GB (1)