Blood Levels of Sevoflurane and Desflurane

NCT03015350 | Completed

• 1 other identifier: One lung ventilation
• Study Type: observational
• Target: 16
• Locations: 1 country
• Sites: 1

Brief Summary

16 patients with American Society of AnesthesioIogy (ASA) physical status I-III will recruited to this study. Patients will divided to the 2 groups. %1.5 Sevoflurane will apply in Group S and %6 Desflurane will apply in Group D. Each groups will divide 2 subgroups. Two lung ventilation will be performed to Group Sa and Group Da, one lung ventilation will be performed to Group Sb and Group Db. At the time point 40.minutes first blood sample will given from patients. Blood sample will be taken at intervals of 10 minutes from groups of two lung ventilation. In groups of one lung ventilation, blood samples will be taken at the time interval of 10 minutes after one lung ventilation started. All blood samples will be assess in Gas Chromatography.

Conditions

Anesthetics, Inhalation

Keywords

blood sevoflurane concentration; blood desflurane concentration; one lung ventilation

Outcome Measures

Primary Outcomes (1)

• Measurement of blood levels of Sevoflurane and Desflurane

  Data collections will be ensured from arterial and venous blood sample and than samples will be assessed with gas chromatography and blood sevoflurane and desflurane level will be measured. Blood samples will take every 10 minutes. Only blood levels of sevoflurane and desflurane will be assessed.

  from 40th minute to the end of the operation

Secondary Outcomes (1)

• determine of ventilation-perfusion mismatch with p(A-a)O2

  from 40th minute to the end of the one lung ventilation

Study Arms (4)

two lung ventilation of Sevoflurane

In GroupSa, 1,5 % sevoflurane will be apply continuously and blood samples will be taken at intervals of 10 minutes starting from the 40th minute.

Drug: Sevoflurane

one lung ventilation of Sevoflurane

In GroupSa, 1,5 % sevoflurane will be apply continuously and first samples will taken at the 40. minutes and collection of blood samples will be continue at intervals of 10 minutes after one lung ventilation started.

Drug: Sevoflurane

two lung ventilation of Desflurane

In GroupSa, 6 % desflurane will be apply continuously and blood samples will be taken at intervals of 10 minutes starting from the 40th minute.

Drug: Desflurane

one lung ventilation of desflurane

In GroupSa, 6 % desflurane will be apply continuously and first samples will taken at the 40. minutes and collection of blood samples will be continue at intervals of 10 minutes after one lung ventilation started.

Drug: Desflurane

Interventions

Sevoflurane DRUG

Measurement of blood desflurane level during one lung ventilation

Also known as: Blood sevoflurane level

one lung ventilation of Sevoflurane; two lung ventilation of Sevoflurane

Desflurane DRUG

Measurement of blood desflurane level during one lung ventilation

Also known as: Blood desflurane level

one lung ventilation of desflurane; two lung ventilation of Desflurane

Eligibility Criteria

• Age: 25 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

16 patients with ASA I-III who undergo thoracotomy or abdominal surgery

You may qualify if:

• Who undergo thoracotomy or abdominal surgery

You may not qualify if:

• ASA IV and up patients
• Patients who taken inotropic agent

Sponsors & Collaborators

• Cukurova University: lead

Study Sites (1)

Ebru Biricik

Adana, In the USA Or Canada, Please Select..., 01380, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Respiratory Aspiration

Interventions

Sevoflurane; Desflurane

Condition Hierarchy (Ancestors)

Respiration Disorders; Respiratory Tract Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Methyl Ethers; Ethers; Organic Chemicals; Hydrocarbons, Fluorinated; Hydrocarbons, Halogenated; Hydrocarbons; Ethyl Ethers

Study Officials

• Ebru Biricik, MD

  Cukurova University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD, Anesthesiology specialist

Study Record Dates

• First Submitted: December 27, 2016
• First Posted: January 10, 2017
• Study Start: December 1, 2016
• Primary Completion: December 1, 2017
• Study Completion: December 1, 2017
• Last Updated: March 5, 2018

Record last verified: 2017-11

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)