CD36 in Nutrient Delivery and Its Dysfunction
Role of CD36 in Nutrient Delivery and Its Dysfunction in African Americans
Sponsor study identifier
interventional
26
1 country
1
Study Start
January 2017
Actual (reported)Primary Completion
July 2021
Actual (reported)Study Completion
July 31, 2021
Actual (reported)This proposal will test the hypothesis that chronic treatment with sildenafil with and without the use of nitric oxide substrate, L-arginine, protects against fatty acid induced impairment of endothelial function, improves insulin-stimulated microvascular recruitment, insulin sensitivity and glucose uptake in CD36 rs3211938 G-allele carriers.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
July 31, 2021
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
January 2017
Actual (reported)January 3, 2017
Actual (reported)January 6, 2017
Actual (reported)July 2021
Actual (reported)July 31, 2021
Actual (reported)November 30, 2022
Actual (reported)Change in Microvascular Blood Volume (MBV) During Insulin Infusion
Insulin induces microvascular recruitment. Changes in MBV during Insulin infusion signifies insulin sensitivity. MBV is measured in the forearm brachioradialis muscle with contrast enhanced ultrasonography during minutes 120-150 of a hyperinsulinaemic euglycaemic (HIE) clamp (insulin infusion rate up to 80 mU/m2.min-1 ). In the last 30 minutes, L-arginine was infused (10 mg/kg/min for 30 minutes) and ultrasound measurements were repeated upon infusion completion (approximately minute 180).
Baseline to end of procedure (approximately 180 minutes)
Change in Microvascular Blood Volume (MBV) During Insulin Infusion After 4 Weeks of Sildenafil Treatment in Both Groups
Chronic treatment with sildenafil increases vascularity and muscle glucose uptake. Changes in MBV during Insulin infusion signifies insulin sensitivity . Insulin sensitivity was tested after 4 weeks of treatment with Sildenafil in both groups. Subjects receive IV infusion of 20% Intralipid (45ml/h) and heparin (200 units/hr). MBV is measured in the forearm brachioradialis muscle with contrast enhanced ultrasonography during minutes 120-150 of a HIE clamp (insulin infusion rate up to 80 mU/m2.min-1 ) In the last 30 minutes, L-arginine was infused (10 mg/kg/min for 30 minutes) and ultrasound measurements were repeated upon infusion completion (approximately minute 180).
Baseline to 4 weeks
Sildenafil citrate 20 mg three times a day
chronic use of phosphodiesterase 5 inhibitor in G allele carrier
chronic use of phosphodiesterase 5 inhibitor in Non G allele carrier
Vanderbilt University Medical Center
Nashville, Tennessee, 37232, United States
Shibao CA, Peche VS, Pietka TA, Samovski D, Williams IM, Abumrad NN, Gamazon ER, Goldberg IJ, Wasserman DH, Abumrad NA. Microvascular insulin resistance with enhanced muscle glucose disposal in CD36 deficiency. Diabetologia. 2025 Mar;68(3):662-675. doi: 10.1007/s00125-024-06292-4. Epub 2024 Nov 6.
Cyndya Shibao, MD
Vanderbilt University Medical Center
26 participants (actual enrollment reported by the registry).
First Submitted
January 3, 2017
First Posted
January 6, 2017
Study Start
January 2017
Actual (reported)Effect of Salicylate on Glucose Metabolism in Insulin Resistance States
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Contact the study team to confirm eligibility.
Primary Completion
July 2021
Actual (reported)Study Completion
July 31, 2021
Actual (reported)Last Updated
November 30, 2022
Results First Posted
November 30, 2022
Record last verified: 2022-11
Download the complete ClinicalTrials.gov record imported by Syfrah, including fields not shown in this page. The registry may contain a newer revision.
Source: ClinicalTrials.gov.
JSON downloads include source attribution and retrieval details alongside the unchanged original record or the separately normalized values.
Source retrieved: