Effects of Aerobic Exercise on CD4 Count,Viral Load,Selected Psycho-social Trait

NCT03009149 | Unknown Early Phase 1

• 1 other identifier: ERC0771/2016
• Study Type: interventional
• Target: 58
• Locations: 0 countries
• Sites: N/A

Brief Summary

H1 - Aerobic exercise will expect to experience significant increase on CD4 counts , reduced viral load , improve psycho-social well being among people living with HIV /AIDS.

Conditions

HIV

Outcome Measures

Primary Outcomes (3)

• CD4 count

  Amount of Cd4 will measure with in one ml blood sample

  12 weeks

• Effects of aerobic exercise on psycho-social

  psycho-social will measure by stander questioner called WHOQOL-briff

  12 weeks

• viral load change duo to aerobic exercise

  viral load will measured with in one milliliter of blood

  12 weeks

Study Arms (1)

AEROBIC EXERCISE

EXPERIMENTAL

The effects of 12 week aerobic exercise will record

Other: Aerobic exercise

Interventions

Aerobic exercise OTHER

Aerobic exercise will perform 3 days per week

AEROBIC EXERCISE

Eligibility Criteria

• Age: 30 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Both female and male under ART
• The distribution of HIV prevalence also varies by age peaking in the 30-40 years age group compared to the other (FDRE,2014) . Because of this the 30-40 will be selected.
• Participants who have been on first line antiretroviral therapy will be selected.
• Willing and able to give an informed and agree consent
• Free of HIV/AIDS related chronic infections that do not allowed aerobic exercise

You may not qualify if:

• Participants with a history of central nervous system dysfunction, hemiparesis (paralysis of one side of the body).
• Diabetic patients
• Participant on either as prophylaxis such as the use of antibiotics to prevent infections or as part of (tuberculosis)TB treatment
• Pregnant and lactating women
• Free of risk factors those are series cardiac problem
• Participant who remain in study area throughout the period of study

Sponsors & Collaborators

• Mekelle University: lead

Related Publications (10)

• Terry L, Sprinz E, Stein R, Medeiros NB, Oliveira J, Ribeiro JP. Exercise training in HIV-1-infected individuals with dyslipidemia and lipodystrophy. Med Sci Sports Exerc. 2006 Mar;38(3):411-7. doi: 10.1249/01.mss.0000191347.73848.80.

  PMID: 16540826 BACKGROUND

• Terry L, Sprinz E, Ribeiro JP. Moderate and high intensity exercise training in HIV-1 seropositive individuals: a randomized trial. Int J Sports Med. 1999 Feb;20(2):142-6. doi: 10.1055/s-2007-971108.

  PMID: 10190777 BACKGROUND

• Stringer WW. HIV and aerobic exercise. Current recommendations. Sports Med. 1999 Dec;28(6):389-95. doi: 10.2165/00007256-199928060-00002.

  PMID: 10623982 BACKGROUND

• Smith BA, Neidig JL, Nickel JT, Mitchell GL, Para MF, Fass RJ. Aerobic exercise: effects on parameters related to fatigue, dyspnea, weight and body composition in HIV-infected adults. AIDS. 2001 Apr 13;15(6):693-701. doi: 10.1097/00002030-200104130-00004.

  PMID: 11371683 BACKGROUND

• Gomes RD, Borges JP, Lima DB, Farinatti PT. Effects of physical exercise in the perception of life satisfaction and immunological function in HIV-infected patients: Non-randomized clinical trial. Rev Bras Fisioter. 2010 Sep-Oct;14(5):390-5. English, Portuguese.

  PMID: 21180864 BACKGROUND

• Ramirez-Marrero FA, Smith BA, Melendez-Brau N, Santana-Bagur JL. Physical and leisure activity, body composition, and life satisfaction in HIV-positive Hispanics in Puerto Rico. J Assoc Nurses AIDS Care. 2004 Jul-Aug;15(4):68-77. doi: 10.1177/1055329003261966.

  PMID: 15296660 BACKGROUND

• Perna FM, LaPerriere A, Klimas N, Ironson G, Perry A, Pavone J, Goldstein A, Majors P, Makemson D, Talutto C, Schneiderman N, Fletcher MA, Meijer OG, Koppes L. Cardiopulmonary and CD4 cell changes in response to exercise training in early symptomatic HIV infection. Med Sci Sports Exerc. 1999 Jul;31(7):973-9. doi: 10.1097/00005768-199907000-00009.

  PMID: 10416558 BACKGROUND

• O'Brien K, Nixon S, Tynan AM, Glazier R. Aerobic exercise interventions for adults living with HIV/AIDS. Cochrane Database Syst Rev. 2010 Aug 4;2010(8):CD001796. doi: 10.1002/14651858.CD001796.pub3.

  PMID: 20687068 BACKGROUND

• Nixon S, O'Brien K, Glazier RH, Tynan AM. Aerobic exercise interventions for adults living with HIV/AIDS. Cochrane Database Syst Rev. 2005 Apr 18;(2):CD001796. doi: 10.1002/14651858.CD001796.pub2.

  PMID: 15846623 BACKGROUND

• Nixon S, O'Brien K, Glazier RH, Tynan AM. Aerobic exercise interventions for adults living with HIV/AIDS. Cochrane Database Syst Rev. 2002;(2):CD001796. doi: 10.1002/14651858.CD001796.

  PMID: 12076422 BACKGROUND

MeSH Terms

Interventions

Exercise

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Girma Mr Tilahun, MSc

  phd Scholar

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: early phase 1
• Allocation: NA
• Masking: NONE
• Purpose: SUPPORTIVE CARE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: PHD scholar

Study Record Dates

• First Submitted: December 8, 2016
• First Posted: January 4, 2017
• Study Start: November 1, 2016
• Primary Completion: January 1, 2017
• Study Completion: February 1, 2017
• Last Updated: January 4, 2017

Record last verified: 2016-12