MP-AzeFlu Allergen Chamber - Onset of Action Study

NCT03004131 | Completed Phase 4

• 1 other identifier: X-03065-3311
• Study Type: interventional
• Target: 82
• Locations: 1 country
• Sites: 1

Brief Summary

This study is to assess the onset of action of fixed drug combination of azelastine hydrochloride and fluticasone propionate nasal spray (MP-AzeFlu) in treating the nasal symptoms of seasonal allergic rhinitis (SAR) induced by an allergen challenge in an Environmental Exposure Chamber (EEC).

Conditions

Seasonal Allergic Rhinitis

Outcome Measures

Primary Outcomes (1)

• Total Nasal Symptom Score (TNSS); change from baseline over the last 4 hours of exposure in an Environmental Exposure Chamber (EEC)

  Onset of action (first significant difference to placebo) up to 4 hours.

Study Arms (3)

fixed drug combination

EXPERIMENTAL

MP29-02 or MP-AzuFlu as fixed drug combination of azelastine hydrochloride and fluticasone propionate nasal spray (Dymista) plus Placebo tablet

Drug: Azelastine hydrochloride + fluticasone propionate nasal spray

Placebo

PLACEBO COMPARATOR

Nasal spray with no active dose plus Placebo tablet

Drug: Placebos

active control

ACTIVE COMPARATOR

fluticasone propionate nasal spray (Flonase) plus loratadine 10 mg tablets (Claritin)

Drug: fluticasone propionate nasal spray + loratadine

Interventions

Azelastine hydrochloride + fluticasone propionate nasal spray DRUG

fixed drug combination

Placebos DRUG

Placebo

fluticasone propionate nasal spray + loratadine DRUG

active control

Eligibility Criteria

• Age: 18 Years - 55 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Provide written informed consent.
• Male or female subjects (childbearing and non-childbearing potential, defined as females with no menstruation for a minimum of 12 months prior to screening) aged 18 to 55 years (inclusive) at screening.
• History of SAR to ragweed pollen for at least the previous 2 ragweed pollen seasons.
• Positive skin prick test (SPT) response to ragweed pollen (allergen induced wheal diameter at least 3 mm larger than the negative control). A test performed in the previous 12 months may be used to qualify the subject.
• To be eligible for Visit 2 EEC, a subject must additionally comply with the following criteria:
• Asymptomatic or with mild symptoms during the baseline recording of symptoms prior to start of the screening EEC (Visit 2):
• \- TNSS ≤ 3/12 with the score for each symptom being less than 2.
• To be eligible for Visit 3, a subject must additionally comply with the following criteria during Visit 2 EEC:
• Demonstrate adequate symptomology:
• \- TNSS ≥ 6/12 on at least two ePDAT™ time point assessments during hours 0-2 in the EEC (Visit 2), with at least one occurring during the last two time points. Additionally, subjects will be required to meet a score of at least 2/3 for runny nose at least twice during hours 0-2 in the EEC, with at least one occurring during the last two time points.
• To be eligible for randomisation (Visit 3), a subject must additionally comply with the following criteria:
• Demonstrate adequate symptomology:
• TNSS ≥ 6/12 on at least two ePDAT™ time point assessments during hours 0-2 in the EEC (Visit 3), with at least one occurring during the last two time points. Additionally, subjects will be required to meet a score of at least 2/3 for runny nose at least twice during hours 0-2 in the EEC, with at least one occurring during the last two time points.
• No evidence of complete nasal blockage on either one or both sides on anterior rhinoscopy within 30 minutes prior to dosing.

You may not qualify if:

• Safety concerns:
• History of allergic reaction to fluticasone propionate, azelastine hydrochloride, loratadine, or one of the excipients of the study treatments (e.g. benzalkonium chloride, phenylethyl alcohol, microcrystalline cellulose) or a component of the container.
• History of anaphylaxis, cardiovascular, pulmonary, hepatic, renal, gastrointestinal, haematological, endocrine, metabolic, psychiatric, neurological, or other disease at screening that may affect subject safety during the study or evaluation of the study endpoints at the discretion of the Investigator and/or designee.
• Subjects with a current diagnosis of asthma or subjects with measured FEV1 \<75% of the predicted value.
• Pregnant, breast-feeding or planning a pregnancy during the study and women of childbearing potential not using adequate contraception. Women of childbearing potential not abstinent or using a highly effective method of birth control defined as those which result in a low failure rate (i.e. \<1% per year) when used consistently and correctly such as implants, injectables, combined oral contraceptives, hormonal IUDs, tubal ligation or vasectomised partner started at least 4 weeks prior to screening.
• Lack of suitability for the study:
• Previous and concomitant treatments: use of prohibited therapies (Antihistaminic agents,Theophylline, Cromolyn sodium, Corticosteroids, Decongestants, Immunotherapy, Systemic antibiotics, any cytochrome P450 3A4 inhibiting or inducing drug \[e.g. ritonavir, ketoconazole, itraconazole, erythromycin, cimetidine, rifampicin, St. John's wort (Hypericum perforatum) etc.\], Tricyclic antidepressants and MAO inhibitors ); and use of any medication considered to have an influence on the outcome of the study during the EEC session, at the discretion of the Investigator and/or designee.
• Subjects with (expected) clinically relevant symptoms at the timing of the scheduled EEC assessments due to concomitant sensitization, i.e., positive SPT (mean wheal diameter at least 3 mm larger than the negative control) and a history of allergic response to the causative allergen, at the discretion of the Investigator. Subjects with a positive SPT for cats and/or dogs are acceptable if the subject avoids cats and/or dogs for the duration of the study.
• Concomitant diseases: abnormalities during the screening visit that might interfere with study results as determined by the Investigator and/or designee.
• Presence of a severely deviated septum, septal perforation, structural nasal defect or large nasal polyps causing obstruction as determined by the Investigator.
• Acute conditions: any acute illness within 7 days prior to the screening visit, including acute conjunctivitis or any other ocular infection.
• History of increased ocular pressure, glaucoma and/or cataracts.
• Tuberculosis, untreated local or systemic fungal or bacterial infections, systemic viral or parasitic infections or ocular herpes simplex.
• Recent nasal ulcers, mucosal erosion, nasal surgery, or nasal trauma, as judged by the Investigator.
• Exposure to chickenpox or measles within 4 weeks prior to the screening visit or during the study.

Sponsors & Collaborators

• MEDA Pharma GmbH & Co. KG: lead

Study Sites (1)

Inflamax Research

Mississauga, Ontario, L4W1Ae, Canada

Location

MeSH Terms

Conditions

Rhinitis, Allergic, Seasonal

Interventions

azelastine; Loratadine

Condition Hierarchy (Ancestors)

Rhinitis, Allergic; Rhinitis; Nose Diseases; Respiratory Tract Diseases; Respiratory Hypersensitivity; Otorhinolaryngologic Diseases; Hypersensitivity, Immediate; Hypersensitivity; Immune System Diseases

Intervention Hierarchy (Ancestors)

Cyproheptadine; Dibenzocycloheptenes; Benzocycloheptenes; Polycyclic Aromatic Hydrocarbons; Hydrocarbons, Aromatic; Hydrocarbons, Cyclic; Hydrocarbons; Organic Chemicals; Piperidines; Heterocyclic Compounds, 1-Ring; Heterocyclic Compounds; Polycyclic Compounds

Study Officials

• Christine Kolb

  MEDA Pharma GmbH & Co. KG

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: phase 4
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Purpose: TREATMENT
• Intervention Model: CROSSOVER
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 16, 2016
• First Posted: December 28, 2016
• Study Start: January 7, 2017
• Primary Completion: March 29, 2017
• Study Completion: March 29, 2017
• Last Updated: February 22, 2022

Record last verified: 2017-05

Locations

CA (1)