Meta-analysis of Soluble Fiber Consumption on Body Weight, Glycemia, and Insulinemia in Overweight and Obese Adults.

NCT03003897 | Completed

• 1 other identifier: Soluble Fiber Review
• Study Type: observational
• Target: 609
• Locations: 1 country
• Sites: 1

Brief Summary

Dietary fiber intake is protective against overweight and obesity; however, a significant fiber gap exists between consumption and recommended intake values. Soluble fiber beneficially impacts metabolism, and supplementation may be a feasible approach to improve body composition and glycemia in overweight and obese individuals. The investigators will evaluate results of randomized controlled trials (RCTs) of soluble fiber supplementation among overweight and obese adults for outcomes related to weight management (e.g. body mass index \[BMI\], body weight, body fat percentage, waist circumference) and glucose and insulin homeostasis (e.g. fasting glucose, homeostasis model assessment of insulin resistance \[HOMA-IR\], fasting insulin) through systematic review and meta-analysis.

Conditions

Obesity

Keywords

Dietary Fiber; Soluble Fiber; Body Mass Index; Body Weight; Blood Glucose; Insulin

Outcome Measures

Primary Outcomes (7)

• Body mass index (kg/m2)

  ≥ 1 week

• Body weight (kg)

  ≥ 1 week

• Body fat (% fat mass)

  ≥ 1 week

• Waist circumference (cm)

  ≥ 1 week

• Fasting glucose (mmol/l)

  ≥ 1 week

• Fasting insulin (pmol/l)

  ≥ 1 week

• Homeostasis Model Assessment of Insulin Resistance (HOMA-IR)

  ≥ 1 week

Study Arms (2)

Soluble Fiber Treatment

Participants receiving soluble fiber.

Other: Soluble Fiber

Placebo Treatment

Participants receiving placebo.

Other: Placebo

Interventions

Soluble Fiber OTHER

Participants receiving soluble fiber.

Soluble Fiber Treatment

Placebo OTHER

Participants receiving placebo.

Placebo Treatment

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Adults ≥ 18 years of age with overweight and obesity but without physician diagnosed chronic disease at screening.

You may qualify if:

• Peer-reviewed randomized controlled trials (RCTs) will be included in the systematic review and meta-analysis if they involve participants who are:
• Overweight or obese (BMI ≥ 25.0 kg/m2 for U.S. populations and ≥ 23.0 kg/m2 for Asian populations and/or waist circumference ≥ 40 inches (94 cm) in men or ≥ 35 inches (80 cm) in women and/or waist-to-hip ratio ≥ 0.90 in men or ≥ 0.85 in women).
• Weight stable and not actively trying to lose weight at screening.
• Without physician-diagnosed chronic conditions at screening (e.g., dyslipidemia, hypertension, type 2 diabetes, and cardiovascular disease).
• Included studies will be soluble fiber supplementation interventions that are controlled feeding studies or conducted among free-living subjects that provide data for outcomes of interest.

You may not qualify if:

• Studies will be excluded from the systematic review and meta-analysis if they meet any of the following criteria:
• Studies conducted in animals.
• Mechanistic research.
• Human trials involving pregnant women, breastfeeding women, or children.
• Conference proceedings.
• Articles not published in English.
• Studies less than 1 week in duration.
• Studies that pool outcome measure data for healthy weight and overweight and obese individuals.
• Studies involving whole food treatments or high fiber profile diets.
• Weight loss interventions involving other tactics, such as counseling or energy restriction.

Sponsors & Collaborators

• University of Illinois at Urbana-Champaign: lead

Study Sites (1)

University of Illinois, Urbana-Champaign

Urbana, Illinois, 61801, United States

Location

Related Publications (1)

• Thompson SV, Hannon BA, An R, Holscher HD. Effects of isolated soluble fiber supplementation on body weight, glycemia, and insulinemia in adults with overweight and obesity: a systematic review and meta-analysis of randomized controlled trials. Am J Clin Nutr. 2017 Dec;106(6):1514-1528. doi: 10.3945/ajcn.117.163246. Epub 2017 Nov 1.

  PMID: 29092878 RESULT

MeSH Terms

Conditions

Obesity; Body Weight; Insulin Resistance

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Hyperinsulinism; Glucose Metabolism Disorders; Metabolic Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 28, 2016
• First Posted: December 28, 2016
• Study Start: January 1, 2016
• Primary Completion: August 1, 2017
• Study Completion: October 1, 2017
• Last Updated: July 10, 2018

Record last verified: 2018-07

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)