Effects of Short-term Curcumin and Multi-polyphenol Supplementation on the Anti-inflammatory Properties of HDL

NCT02998918 | Completed Results

• 1 other identifier: Pro00055882
• Study Type: interventional
• Target: 21
• Locations: 1 country
• Sites: 1

Brief Summary

Polyphenol supplements, including curcumin and resveratrol, are known to decrease inflammation, but previous polyphenol supplements were poorly absorbed and thus their effects were reduced. A new phytosome formulation coats the supplements and allows them to be better absorbed. The purpose of this study is to examine the acute (1-hr) and short-term (1-week) effects of two different phytosome-formulated polyphenol supplements on inflammation. The two supplements that will be used are: 1) PolyResveratrol and 2) Curcumin.

Conditions

Inflammation; Atherosclerosis; Cardiovascular Disease

Keywords

Inflammation; HDL; Anti-inflammatory; Supplementation; Curcumin; polyphenol; V-cam; I-cam; atherosclerosis; cardiovascular disease; atherogenesis; antioxidant; resveratrol; quercetin

Outcome Measures

Primary Outcomes (1)

• Inflammation Change: HDL Plasma

  VCAM-1 expression in HDL plasma will be measured at baseline, and after one week of supplementation for each supplement. Differences in one-week changes in inflammation between each supplement will be compared.

  One week

Study Arms (2)

PolyResveratrol Supplementation

EXPERIMENTAL

Participants take 500 mg of PolyResveratrol (100 mg curcumin phytosome, 100 mg quercetin phytosome, 100 mg green tea phytosome, 100 mg trans-resveratrol, 100 mg trans-pterostilbene; Thorne Research) twice daily for one week. Two blood Draws are taken on both the first and last days of the week. One blood draw is done fasted just before consumption of one supplement dose, and one blood draw is done after consumption of one supplement dose.

Dietary Supplement: PolyResveratrol Supplementation

Curcumin Supplementation

EXPERIMENTAL

Participants take 500 mg of Curcumin phytosome twice daily for one week. Two blood draws are taken on both the first and last days of the week. One blood draw is done fasted just before consumption of one supplement dose, and one blood draw is done after consumption of one supplement dose.

Dietary Supplement: Curcumin Supplementation

Interventions

PolyResveratrol Supplementation DIETARY_SUPPLEMENT

Participants will take 1 mg of a polyresveratrol phytosome supplement each day for one week. The acute effect (1 hr) of one 500 mg dose of the polyresveratrol phytosome supplement on inflammation will be examined along with the short-term effect (1 week).

PolyResveratrol Supplementation

Curcumin Supplementation DIETARY_SUPPLEMENT

Participants will take 1 mg of a curcumin phytosome supplement each day for one week. The acute effect (1 hr) of one 500 mg dose of the curcumin phytosome supplement on inflammation will be examined along with the short-term effect (1 week).

Curcumin Supplementation

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• General good health
• Between 18 and 60 years old
• Non-smoker
• Not taking any medications or dietary supplements

You may not qualify if:

• Taking prescription anti-inflammatory drugs or supplements/drugs that may affect inflammation

Sponsors & Collaborators

• University of South Carolina: lead

Study Sites (1)

Clinical Exercise Research Center

Columbia, South Carolina, 29201, United States

Location

Related Publications (24)

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MeSH Terms

Conditions

Inflammation; Atherosclerosis; Cardiovascular Diseases

Condition Hierarchy (Ancestors)

Pathologic Processes; Pathological Conditions, Signs and Symptoms; Arteriosclerosis; Arterial Occlusive Diseases; Vascular Diseases

Limitations and Caveats

The planned assays did not work in the stored specimens. Thus, data will not be reported for this trial

Results Point of Contact

• Title: Mark Sarzynski
• Organization: University of South Carolina

sarz@mailbox.sc.edu

8037779510

Study Officials

• Mark Sarzynski

  University of South Carolina

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: No
• Restrictive Agreement: No

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: October 18, 2016
• First Posted: December 21, 2016
• Study Start: September 1, 2016
• Primary Completion: July 1, 2017
• Study Completion: June 1, 2020
• Last Updated: November 18, 2023
• Results First Posted: November 18, 2023

Record last verified: 2023-11

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)