FLT-PET for Early Detection of Relapse in Patients With Irradiated Lung Cancer
1 other identifier
interventional
64
1 country
2
Brief Summary
This study investigates the feasibility of FLT-PET to improve the diagnosis of relapse in patients with irradiated lung cancer in comparison with FDG-PET/CT.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable
Started Nov 2014
Longer than P75 for not_applicable
2 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
November 1, 2014
CompletedFirst Submitted
Initial submission to the registry
December 9, 2016
CompletedFirst Posted
Study publicly available on registry
December 19, 2016
CompletedPrimary Completion
Last participant's last visit for primary outcome
February 7, 2019
CompletedStudy Completion
Last participant's last visit for all outcomes
February 7, 2020
CompletedMay 9, 2022
May 1, 2022
4.3 years
December 9, 2016
May 3, 2022
Conditions
Outcome Measures
Primary Outcomes (1)
Number of patients with local and/or regional relapse
6 months
Study Arms (1)
FLT-PET
EXPERIMENTALInterventions
Eligibility Criteria
You may qualify if:
- history with lung cancer, small cell or non-small cell
- radiotherapy of lung cancer ended within the last 24 months
- radiotherapy might be normofractionated or stereotactic
- current suspicion of relapse
- written and oral consent
You may not qualify if:
- communication difficulties
- pregnancy or lactation
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (2)
Dept. of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet
Copenhagen, 2100, Denmark
Dept. Respiratory Medicine, Bispebjerg University Hospital
Copenhagen, 2400, Denmark
Related Publications (2)
Christensen TN, Langer SW, Persson G, Larsen KR, Loft A, Amtoft AG, Berthelsen AK, Johannesen HH, Keller SH, Kjaer A, Fischer BM. 18F-FLT PET/CT Adds Value to 18F-FDG PET/CT for Diagnosing Relapse After Definitive Radiotherapy in Patients with Lung Cancer: Results of a Prospective Clinical Trial. J Nucl Med. 2021 May 10;62(5):628-635. doi: 10.2967/jnumed.120.247742. Epub 2020 Oct 9.
PMID: 33037090RESULTChristensen TN, Langer SW, Persson G, Larsen KR, Amtoft AG, Keller SH, Kjaer A, Fischer BM. Impact of [18F]FDG-PET and [18F]FLT-PET-Parameters in Patients with Suspected Relapse of Irradiated Lung Cancer. Diagnostics (Basel). 2021 Feb 11;11(2):279. doi: 10.3390/diagnostics11020279.
PMID: 33670242RESULT
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY CHAIR
Andreas Kjær, MD phD MDSci
Dept of Clinical Physiology, Nuclear medicine and PET, Rigshospitalet, Denmark
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NA
- Masking
- NONE
- Purpose
- DIAGNOSTIC
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- MD, research fellow
Study Record Dates
First Submitted
December 9, 2016
First Posted
December 19, 2016
Study Start
November 1, 2014
Primary Completion
February 7, 2019
Study Completion
February 7, 2020
Last Updated
May 9, 2022
Record last verified: 2022-05