Banana Cultivars and Exercise Performance and Recovery

NCT02994628 | Completed

• 1 other identifier: 16-0071
• Study Type: interventional
• Target: 23
• Locations: 1 country
• Sites: 1

Brief Summary

In a previous study at the Appalachian State University (ASU) Human Performance Laboratory at the North Carolina Research Campus (NCRC), investigators showed that cyclists ingesting about one-half of a banana with water every 15 minutes cycled 75-km faster (5%) than with water alone. The polyphenols (i.e., chemicals in plants with health benefits) in the banana improved the capacity to counter oxidative stress, and the sugars lowered post-exercise inflammation. The cyclists reported some gastrointestinal discomfort, however, from the high volume of bananas consumed. Dole Foods, the sponsor of this study, has a banana collection that includes many different varieties, including the Mini banana that has a higher sugar (50%) and phenolic (63%) content than the typical banana (Cavendish) available in stores. Thus athletes should experience similar performance benefits from a smaller volume of Mini compared to Cavendish bananas, and reduced gastrointestinal symptoms. If study results are favorable, Dole Foods may market the Mini banana as the "sport" banana. The purpose of this study is to compare ingestion of Mini and Cavendish bananas with an equicaloric, sugar-only beverage or water on 75-km cycling performance and post-exercise oxidative capacity and stress, inflammation, immune function, muscle damage and soreness, and gastrointestinal symptoms.

Conditions

Inflammation

Keywords

oxidative stress; immune function; muscle damage; carbohydrate; polyphenols; cycling

Outcome Measures

Primary Outcomes (1)

• Change in total plasma concentrations of inflammatory cytokines

  Total plasma concentrations of five inflammatory cytokines \[monocyte chemoattractant protein-1 (MCP-1), tumor necrosis factor alpha (TNFα), IL-6, IL-8, and IL-10\] will be determined using an electrochemiluminescence based solid-phase sandwich immunoassay (Meso Scale Discovery, Gaithersburg,MD, USA).

  Pre-exercise, and post-exercise (0, 0.75, 1.5, 3.0, 4.5, 21, 45 hours)

Secondary Outcomes (6)

• Change in concentration of serum myoglobin

  Pre-exercise, and post-exercise (0, 0.75, 1.5, 3.0, 4.5, 21, 45 hours)

• Change in muscle concentration of glycogen

  Pre-exercise, and post-exercise (0 hours)

• Change in self-reported gastrointestinal and mental symptoms from a short questionnaire

  Pre-exercise, and post-exercise (0 hours)

• Change in concentration of ferric reducing ability of plasma (FRAP)

  Pre-exercise, and post-exercise (0, 0.75, 1.5, 3.0, 4.5, 21, 45 hours)

• Change in plasma concentration of oxidized low density lipoprotein

  Pre-exercise, and post-exercise (0, 0.75, 1.5, 3.0, 4.5, 21, 45 hours)

Study Arms (4)

Water

ACTIVE COMPARATOR

Intervention, water and no banana carbohydrate: consume 3 ml/kg water every 15 min during 75 km cycling

Other: Water

Mini banana

EXPERIMENTAL

Intervention, banana carbohydrate: ingest 0.2 g carbohydrate/kg body weight from Mini banana with 3 ml/kg water every 15 minutes during 75 km cycling

Other: Mini banana

Cavendish banana

EXPERIMENTAL

Intervention, banana carbohydrate: ingest 0.2 g carbohydrate/kg body weight from Cavendish banana with 3 ml/kg water every 15 minutes during 75 km cycling

Other: Cavendish banana

6% sugar beverage

EXPERIMENTAL

Intervention: pure banana carbohydrate in sugar beverage; ingest 0.2 g carbohydrate/kg body weight from a 6% sugar beverage every 15 minutes during 75 km cycling (contains 60 grams sugar per liter using the same sugar profile found in Cavendish bananas)

Other: 6% sugar beverage

Interventions

Water OTHER

Water only without carbohydrate

Water

Mini banana OTHER

Ingest mini banana containing higher phenolics and carbohydrate concentration

Mini banana

Cavendish banana OTHER

Ingest Cavendish banana (common banana)

Cavendish banana

6% sugar beverage OTHER

Ingest 6% sugar beverage containing same glucose and fructose profile as banana

6% sugar beverage

Eligibility Criteria

• Age: 18 Years - 55 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy, with no known cardiovascular disease, diabetes, or cancer.
• Non-smoker.
• Regularly compete in road races (category 1 to 5) and/or capable of cycling 75 km in a laboratory setting (using own bicycles on CompuTrainer training systems).
• Agree to train normally, maintain weight, and avoid the regular use of large-dose vitamin and mineral supplements, herbs, and medications that influence inflammation and immune function (in particular, Advil, Motrin, aspirin and similar anti-inflammatory drugs) for the duration of the 7 to 8-week study. If in doubt, discuss supplement/medication use with the Research Manager.
• Categorized as "low risk" using the American College of Sports Medicine screening questionnaire.

You may not qualify if:

• Inability to comply with study requirements.
• Any other concurrent condition which, in the opinion of the primary investigator (PI), would preclude participation in this study or interfere with compliance.
• Current diagnosis of cardiovascular disease, diabetes, or cancer (except for non-melanoma skin cancer).

Sponsors & Collaborators

• Appalachian State University: lead
• Dole Food Company: collaborator

Study Sites (1)

Human Performance Lab, North Carolina Research Campus

Kannapolis, North Carolina, 28081, United States

Location

Related Publications (3)

• Nieman DC, Gillitt ND, Sha W, Meaney MP, John C, Pappan KL, Kinchen JM. Metabolomics-Based Analysis of Banana and Pear Ingestion on Exercise Performance and Recovery. J Proteome Res. 2015 Dec 4;14(12):5367-77. doi: 10.1021/acs.jproteome.5b00909. Epub 2015 Nov 23.

  PMID: 26561314 BACKGROUND

• Nieman DC, Gillitt ND, Chen GY, Zhang Q, Sakaguchi CA, Stephan EH. Carbohydrate intake attenuates post-exercise plasma levels of cytochrome P450-generated oxylipins. PLoS One. 2019 Mar 18;14(3):e0213676. doi: 10.1371/journal.pone.0213676. eCollection 2019.

  PMID: 30883596 DERIVED

• Nieman DC, Gillitt ND, Sha W, Esposito D, Ramamoorthy S. Metabolic recovery from heavy exertion following banana compared to sugar beverage or water only ingestion: A randomized, crossover trial. PLoS One. 2018 Mar 22;13(3):e0194843. doi: 10.1371/journal.pone.0194843. eCollection 2018.

  PMID: 29566095 DERIVED

MeSH Terms

Conditions

Inflammation

Interventions

Water

Condition Hierarchy (Ancestors)

Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Hydroxides; Alkalies; Inorganic Chemicals; Anions; Ions; Electrolytes; Oxides; Oxygen Compounds

Study Officials

• David C. Nieman, DrPH

  Appalachian State University, North Carolina Research Campus

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 24, 2015
• First Posted: December 16, 2016
• Study Start: November 1, 2015
• Primary Completion: December 1, 2016
• Study Completion: January 25, 2017
• Last Updated: February 23, 2017

Record last verified: 2016-01

Data Sharing

• IPD Sharing: Will share

Locations

US (1)