Influence of Fluid Challenge on End-Expiratory Lung Impedance in Mechanically Ventilated Patients Monitored With Electrical Impedance Tomography

NCT02992002 | Completed

• 1 other identifier: EIT Fluid Challenge
• Study Type: observational
• Target: 25
• Locations: 1 country
• Sites: 1

Brief Summary

The study investigates the influence of a clinically indicated fluid challenge on end-expiratory lung impedance, assessed by electrical impedance tomography (EIT). EIT data will be collected before, during and after infusion of 500 ml of crystalloid solution in mechanically ventilated patients on an operative intensive care unit.

Conditions

Respiratory Failure; Circulatory Failure; Fluid Responsiveness; Fluid Overload

Outcome Measures

Primary Outcomes (1)

• Change in end-expiratory lung impedance (EELI)

  To assess the effect of fluid challenge on EELI, the change in EELI during the fluid challenge will be measured by electrical impedance tomography and will be compared to the change in EELI during the last 15 minutes before start of the fluid challenge.

  15-30 minutes

Secondary Outcomes (2)

• Correlation between change in end-expiratory lung impedance and change in intrathoracic blood volume

  15-30 minutes

• Fluid responsiveness

  15-30 minutes

Interventions

Fluid Challenge OTHER

Infusion of a standardized amount of crystalloid solution (500 ml) to assess fluid responsiveness by means of changes in cardiac output, assessed by transpulmonary thermodilution.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Mixed population of intensive care unit patients

You may qualify if:

• patients on mechanical ventilation
• clincial decision to monitor regional ventilation with electrical impedance tomography
• clinical indication for fluid challenge
• established cardiac output monitoring with transpulmonary thermodilution

You may not qualify if:

• age \< 18 years
• open lung injuries
• instable injury of spine or cranium
• thoracic metal implants
• body mass index \> 35

Sponsors & Collaborators

• University Hospital Schleswig-Holstein: lead

Study Sites (1)

University Medical Center Schleswig Holstein, Campus Kiel

Kiel, Schleswig-Holstein, 24145, Germany

Location

MeSH Terms

Conditions

Respiratory Insufficiency; Shock; Edema

Condition Hierarchy (Ancestors)

Respiration Disorders; Respiratory Tract Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dr Tobias Becher

Study Record Dates

• First Submitted: December 9, 2016
• First Posted: December 14, 2016
• Study Start: December 1, 2016
• Primary Completion: December 1, 2017
• Study Completion: December 1, 2017
• Last Updated: May 3, 2018

Record last verified: 2018-05

Data Sharing

• IPD Sharing: Will not share

Locations

DE (1)