NCT02984163

Brief Summary

The primary purpose of this proposed 5-year hybrid effectiveness and implementation study is to evaluate the relative benefit from, and implementation of an Alberta wide clinic-to-community-based cancer and exercise model of care - the Alberta Cancer Exercise (ACE) Program. The investigators hypothesize that the strategy will improve the physical well-being and QoL of survivors (on and off cancer treatment) while preventing the development of secondary cancers.

Trial Health

75
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
2,570

participants targeted

Target at P75+ for not_applicable

Timeline
1mo left

Started Jan 2017

Longer than P75 for not_applicable

Geographic Reach
1 country

2 active sites

Status
active not recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress98%
Jan 2017Jun 2026

First Submitted

Initial submission to the registry

December 2, 2016

Completed
4 days until next milestone

First Posted

Study publicly available on registry

December 6, 2016

Completed
1 month until next milestone

Study Start

First participant enrolled

January 9, 2017

Completed
7.7 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

September 30, 2024

Completed
1.7 years until next milestone

Study Completion

Last participant's last visit for all outcomes

June 30, 2026

Expected
Last Updated

August 21, 2025

Status Verified

August 1, 2025

Enrollment Period

7.7 years

First QC Date

December 2, 2016

Last Update Submit

August 19, 2025

Conditions

Neoplasms

Keywords

cancerexercise

Outcome Measures

Primary Outcomes (1)

  • Physical Activity Minutes Per Week

    Change in number of participants meeting Guidelines for Physical Activity of 150 minutes per week of moderate intensity exercise

    Baseline to One-year

Secondary Outcomes (15)

  • Aerobic Endurance

    Baseline to One-year

  • Quality of Life Cancer Specific

    Baseline to One year

  • General Health-related Quality of Life

    Baseline to One-year

  • Fatigue

    Baseline to One-year

  • Upper extremity grip strength

    Baseline to One-year

  • +10 more secondary outcomes

Other Outcomes (4)

  • Home-based programming stepping test

    Baseline to One-year

  • 1RM or 8RM strength (optional)

    Baseline to One-year

  • Muscular endurance test (optional)

    Baseline to One-year

  • +1 more other outcomes

Study Arms (1)

Exercise Intervention

EXPERIMENTAL

Participant exercise sessions will be conducted in groups of 10-15 under the direct supervision of the community-based exercise specialist. Sessions will be twice a week for 12-weeks. Participants will have the option to continue with the exercise program after the 12-weeks on a fee-for-service basis.

Behavioral: Exercise

Interventions

ExerciseBEHAVIORAL

Exercise sessions will include a combination of aerobic, resistance, balance, and flexibility exercises delivered in a circuit-type class setting or group personal training format.

Also known as: Physical Activity
Exercise Intervention

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • have a diagnosis of cancer;
  • be over the age of 18 years;
  • be able to participate in low-intensity levels of activity at minimum;
  • be pretreatment, or receiving active cancer treatment (i.e., surgery, systemic therapy and radiation therapy), or have received cancer treatment within the past 3 years; or have ongoing significant cancer or treatment-related impairments (requiring supportive exercise intervention);
  • be able to provide informed written consent in English.

You may not qualify if:

  • \) Inability or deemed unsafe to participate in physical activity program

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (2)

University of Calgary/ Tom Baker Cancer Centre

Calgary, Alberta, T2N 1N4, Canada

Location

University of Alberta & Cross Cancer Institute

Edmonton, Alberta, T6G 2G4, Canada

Location

Related Publications (1)

  • McNeely ML, Sellar C, Williamson T, Shea-Budgell M, Joy AA, Lau HY, Easaw JC, Murtha AD, Vallance J, Courneya K, Mackey JR, Parliament M, Culos-Reed N. Community-based exercise for health promotion and secondary cancer prevention in Canada: protocol for a hybrid effectiveness-implementation study. BMJ Open. 2019 Sep 13;9(9):e029975. doi: 10.1136/bmjopen-2019-029975.

    PMID: 31519676DERIVED

MeSH Terms

Conditions

NeoplasmsMotor Activity

Interventions

Exercise

Condition Hierarchy (Ancestors)

Behavior

Intervention Hierarchy (Ancestors)

Motor ActivityMovementMusculoskeletal Physiological PhenomenaMusculoskeletal and Neural Physiological Phenomena

Study Officials

  • Margaret L McNeely, PT, PhD

    University of Alberta

    PRINCIPAL INVESTIGATOR

  • Nicole Culos-Reed, PhD

    University of Calgary

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
SUPPORTIVE CARE
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

December 2, 2016

First Posted

December 6, 2016

Study Start

January 9, 2017

Primary Completion

September 30, 2024

Study Completion (Estimated)

June 30, 2026

Last Updated

August 21, 2025

Record last verified: 2025-08

Locations

CA(2)