Amino Acid Balance During Physical Inactivity
1 other identifier
interventional
22
0 countries
N/A
Brief Summary
The aim is to assess the impact of physical inactivity on muscle amino acid balance and forearm glucose uptake. In addition, we will evaluate how high-fat overfeeding will modulate muscle amino acid balance and forearm glucose uptake.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Jan 2017
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
November 30, 2016
CompletedFirst Posted
Study publicly available on registry
December 2, 2016
CompletedStudy Start
First participant enrolled
January 1, 2017
CompletedPrimary Completion
Last participant's last visit for primary outcome
September 1, 2018
CompletedStudy Completion
Last participant's last visit for all outcomes
September 1, 2018
CompletedOctober 25, 2018
October 1, 2018
1.7 years
November 30, 2016
October 23, 2018
Conditions
Outcome Measures
Primary Outcomes (1)
Muscle amino acid balance
Forearm muscle amino acid balance
3 hours
Secondary Outcomes (1)
Glucose uptake
3 hours
Study Arms (2)
Energy-balanced diet
PLACEBO COMPARATORForearm immobilization whilst consuming an energy-balanced diet
High-fat overfeeding
EXPERIMENTALForearm immobilization whilst consuming a high-fat diet, 50% energy excess
Interventions
Eligibility Criteria
You may qualify if:
- BMI between 18 and 30
You may not qualify if:
- Any diagnosed metabolic impairment (e.g. type 1 or 2 Diabetes).
- Any diagnosed cardiovascular disease or hypertension.
- Elevated blood pressure at the time of screening. (An average systolic blood pressure reading of ≥140 mmHg over two or more measurements and an average diastolic blood pressure of ≥90 mmHg over two or more measurements.)
- Chronic use of any prescribed or over the counter pharmaceuticals.
- Regular use of nutritional supplements (e.g. creatine, protein supplementation)
- Metallic implants (including heart pacemaker, cochlear implants, medication pumps, surgical clips, plates or screws).
- A personal or family history of thrombosis, epilepsy, seizures or schizophrenia.
- Any previous motor disorders.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Related Publications (2)
Wall BT, Cruz AM, Otten B, Dunlop MV, Fulford J, Porter C, Abdelrahman DR, Stephens FB, Dirks ML. The Impact of Disuse and High-Fat Overfeeding on Forearm Muscle Amino Acid Metabolism in Humans. J Clin Endocrinol Metab. 2020 Jul 1;105(7):dgaa184. doi: 10.1210/clinem/dgaa184.
PMID: 32303743DERIVEDDirks ML, Wall BT, Otten B, Cruz AM, Dunlop MV, Barker AR, Stephens FB. High-fat Overfeeding Does Not Exacerbate Rapid Changes in Forearm Glucose and Fatty Acid Balance During Immobilization. J Clin Endocrinol Metab. 2020 Jan 1;105(1):dgz049. doi: 10.1210/clinem/dgz049.
PMID: 31609422DERIVED
Study Officials
- PRINCIPAL INVESTIGATOR
Benjamin T Wall, PhD
University of Exeter
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, INVESTIGATOR
- Purpose
- BASIC SCIENCE
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
November 30, 2016
First Posted
December 2, 2016
Study Start
January 1, 2017
Primary Completion
September 1, 2018
Study Completion
September 1, 2018
Last Updated
October 25, 2018
Record last verified: 2018-10
Data Sharing
- IPD Sharing
- Will not share