Can Brief High-intensity Interval Training Mitigate the Adverse Consequences of High-fat Overfeeding?

NCT02177604 | Terminated

• 1 other identifier: 140319
• Study Type: interventional
• Target: 7
• Locations: 1 country
• Sites: 1

Brief Summary

Previous research has shown that indulging in 50% more calories than required for as little as 3 days can significantly impact markers of metabolic health in lean and overweight individuals. Here, the investigators will determine if 3 brief sessions of high-intensity interval training can mitigate the adverse consequences of 7 days high-fat overfeeding in sedentary, overweight males.

Conditions

Insulin Resistance

Outcome Measures

Primary Outcomes (1)

• Change in glucose metabolism

  Changes in insulin and glucose area under the curve assessed via 75g Oral Glucose Tolerance Test.

  1 week

Secondary Outcomes (1)

• Change in plasma levels of cytokines

  1 week

Other Outcomes (3)

• Change in mitochondrial metabolism

  1 week

• Change in resting energy expenditure

  1 week

• Change in cognitive function

  1 week

Study Arms (3)

Wingate HIT

EXPERIMENTAL

7 days of high-fat overfeeding (50% excess calories) in conjunction 3 supervised sessions of Wingate High-intensity Interval Training.

Other: Wingate HIT; Other: High-fat overfeeding

Modified HIT

EXPERIMENTAL

7 days of high-fat overfeeding (50% excess calories) in conjunction with 3 supervised sessions of Modified High-Intensity Interval Training

Other: Modified HIT; Other: High-fat overfeeding

No Exercise Control

ACTIVE COMPARATOR

7 days of high-fat overfeeding (50% excess calories) with no supervised exercise

Other: High-fat overfeeding

Interventions

Wingate HIT OTHER

3 sessions of Wingate based High-Intensity Interval Training (6-8 x 15 second "all out" sprints on a cycle ergometer interspersed by 2 minutes recovery)

Wingate HIT

Modified HIT OTHER

3 sessions of Modified High-Intensity Interval Training (8 x 60 second sprints at approximately 90-95% VO2 peak on a cycle ergometer interspersed by 60 seconds recovery)

Modified HIT

High-fat overfeeding OTHER

7 days of high-fat overfeeding (50% excess calories)

Modified HIT; No Exercise Control; Wingate HIT

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Sedentary (no more than 2 sessions of structured moderate intensity aerobic exercise or resistance training per week)
• Overweight (BMI 25-29.9 kg/m2)

You may not qualify if:

• Personal history of any major illness (i.e. cardiovascular disease, diabetes, hypertension, cancer, renal/liver impairments, major psychiatric disorders, eating disorders etc.)
• History of chest pain (either at rest or during exercise.)
• Abnormal resting ECG at screening visit
• Chronic use of any prescribed or non-prescribed medications (i.e. anti-hypertensive, statins, metformin, anti-inflammatories, antidepressants etc.)
• Blood pressure or blood lipids outside of reference ranges
• Serum ferritin \<30ng/mL
• Uncontrolled asthma, current fever, or upper respiratory infection
• Current intake of \> 140g alcohol/week
• Current smokers of cigarettes/cigars/marijuana
• Current intake of any illicit substance
• Experience claustrophobia in confined spaces
• Donated blood in the past 3 months
• Migraines
• Unable to comprehend study protocol
• Unable to perform exercise on a cycle ergometer at second screening visit

Sponsors & Collaborators

• University of Adelaide: lead
• Royal Adelaide Hospital: collaborator
• University of South Australia: collaborator

Study Sites (1)

South Australian Health & Medical Research Institute

Adelaide, South Australia, 5000, Australia

Location

MeSH Terms

Conditions

Insulin Resistance

Condition Hierarchy (Ancestors)

Hyperinsulinism; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases

Study Officials

• Leonie Heilbronn, PhD

  University of Adelaide

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: June 19, 2014
• First Posted: June 27, 2014
• Study Start: November 1, 2014
• Primary Completion: December 1, 2016
• Study Completion: December 1, 2016
• Last Updated: May 25, 2018

Record last verified: 2018-05

Locations

AU (1)