The Role of Hydration on Exercise Performance - ODIN

NCT02980939 | Completed

• 1 other identifier: 16-10-135
• Study Type: interventional
• Target: 11
• Locations: 1 country
• Sites: 1

Brief Summary

During exercise in the heat, there is a need to replenish fluids in order to avoid dehydration and decrease the risk for heat illness. What drives this urge to drink is the thirst mechanism. Following ingestion of fluids, there is an inhibition of thirst before there is a replenishing of fluids. However, there is little scientific evidence of where thirst is inhibited, if this thirst inhibition is augmented by exercise and how thirst itself influence exercise performance. Further, during rehydration studies, it is very difficult to successfully blind a subject to their drinking/hydration protocol. Previous studies that have blinded a subject to their drinking have used various methods such as intravenous fluid administration and/or nasogastric tubes. Therefore, the purpose of this research is to examine the mechanistic roles thirst inhibition plays while exercising in the heat while undergoing intravenous fluid administration. Specific attention will be directed to the cardiovascular and thermoregulatory function of the individuals. All blood, cardiovascular, thermoregulatory, and perceptual measures are shown in the diagram below.

Conditions

Dehydration

Outcome Measures

Primary Outcomes (1)

• 5km - Cycling Time Trial

  Time to completion 5 km cycling time trial in the heat

  2hour

Secondary Outcomes (1)

• Rectal Temperature

  2hour

Study Arms (2)

Euhydration - no thirst

PLACEBO COMPARATOR

Other: iv fluid infusion

Dehydration - no Thirst

EXPERIMENTAL

Other: iv fluid infusion

Interventions

iv fluid infusion OTHER

Intravenous isotonic saline infusion

Dehydration - no Thirst; Euhydration - no thirst

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Cycling Racing History category 3 or higher USA cycling certification
• maximal oxygen uptake \>55 ml/kg/min

You may not qualify if:

• History of heat stroke
• Renal, cardiovascular, metabolic diseases
• Regular medication

Sponsors & Collaborators

• University of Arkansas, Fayetteville: lead

Study Sites (1)

University of Arkansas - HPER

Fayetteville, Arkansas, 72701, United States

Location

MeSH Terms

Conditions

Dehydration

Condition Hierarchy (Ancestors)

Water-Electrolyte Imbalance; Metabolic Diseases; Nutritional and Metabolic Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Stavros A Kavouras, PhD

  University of Arkansas

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: PREVENTION
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: November 30, 2016
• First Posted: December 2, 2016
• Study Start: November 1, 2016
• Primary Completion: March 18, 2017
• Study Completion: March 18, 2017
• Last Updated: May 31, 2017

Record last verified: 2017-05

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)