Effects of Prolonged Roll-tilt in Healthy Human Subjects

NCT02980419 | Unknown

• 1 other identifier: post_tilt_study
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

The long-term goal of this research is to advance the investigators knowledge of how the brain combines the information of multiple sensory systems coding for spatial oriention and how adaptation to vestibular imbalance influences spatial orientation. In healthy human subjects verticality perception is accurate while upright. After prolonged roll-tilt, humans show a systematic bias in perceived direction towards the previous roll-tilted position (so-called "post-tilt bias"). This effect could either be related to adaptation to the roll-tilted position (shifting the "null" position) or it could be related to changes in torsional eye position due to prolonged static roll-tilt (ocular counter-roll). While in the first case a post-tilt bias is predicted independently of the experimental paradigm used, the second hypothesis predicts a post-tilt bias only if retinal cues are integrated. In order to evaluate these hypotheses, the investigators will assess perceived vertical using both vision-dependent and vision-independent paradigms.

Conditions

Adaptation Reaction

Outcome Measures

Primary Outcomes (1)

• adjustment errors of the subjective visual/haptic/postural vertical in upright position after prolonged whole-body roll-tilt positions.

  the accuracy and precision of visual vertical adjustments after prolonged roll tilt are quantified.

  10 minutes (i.e. short-term adaptation)

Secondary Outcomes (3)

• changes in adjustment errors of the subjective visual vertical when providing an additional optokinetic stimulus

  10 minutes (i.e. short-term adaptation)

• changes in adjustment errors of the subjective haptic vertical when providing an additional optokinetic stimulus

  10 minutes (i.e. short-term adaptation)

• changes in adjustment errors of the subjective postural vertical when providing an additional optokinetic stimulus

  10 minutes (i.e. short-term adaptation)

Study Arms (1)

intervention arm

EXPERIMENTAL

In each participant the investigators will assess verticality perception in whole-body upright position by use of the SVV, the SPV and the SHV after static roll-tilt at ±90deg over 5min. Measurements will be obtained on a motor-driven turntable and two different roll-tilt positions will be applied (±90°). A visual line (SVV), a rod (SHV) or the turntable itself will be adjusted to indicate perceived direction of vertical. A total of three measuring sessions, each lasting about 60 minutes are scheduled.

Behavioral: presentation of visual and vestibular stimuli

Interventions

presentation of visual and vestibular stimuli BEHAVIORAL

In each participant the investigators will assess verticality perception in whole-body upright position by use of the SVV, the SPV and the SHV after static roll-tilt at ±90deg over 5min. Measurements will be obtained on a motor-driven turntable and two different roll-tilt positions will be applied (±90°). A visual line (SVV), a rod (SHV) or the turntable itself will be adjusted to indicate perceived direction of vertical. A total of three measuring sessions, each lasting about 60 minutes are scheduled.

intervention arm

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• ages 18-65 years
• informed consent

You may not qualify if:

• peripheral-vestibular deficit
• disturbed consciousness
• history of sensory deficits
• visual field deficits
• other neurological or systemic disorder which can cause dementia or cognitive dysfunction
• intake of antidepressants, sedatives, or neuroleptics
• pregnancy, unless excluded by a negative pregnancy test
• known neck pain or status post neck trauma

Sponsors & Collaborators

• University of Zurich: lead

Study Sites (1)

University Hospital Zurich, Dept. of Neurology

Zurich, Canton of Zurich, 8091, Switzerland

RECRUITING

Central Study Contacts

Dominik Straumann, MD

CONTACT

+41442551111; dominik.straumann@usz.ch

Alexander A Tarnutzer, MD

CONTACT

+41442551111; alexander.tarnutzer@usz.ch

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 16, 2016
• First Posted: December 2, 2016
• Study Start: June 1, 2016
• Primary Completion: May 1, 2020
• Study Completion: May 31, 2020
• Last Updated: January 7, 2020

Record last verified: 2019-12

Data Sharing

• IPD Sharing: Will not share

Locations

CH (1)