Metabolism of Omega-3 and Omega-6 During Healthy Aging

NCT02957188 | Completed

• 1 other identifier: 13C EPA and 13C AA metabolism
• Study Type: observational
• Target: 13
• Locations: 0 countries
• Sites: N/A

Brief Summary

The purpose of this study is to determine the kinetics of 13C-eicosapentaenoic acid (EPA) and 13C-arachidonic acid (AA) in young and older participants

Conditions

Healthy Volunteers

Keywords

Eicosapentaenoic acid; Arachidonic acid; Metabolism; Healthy aging

Outcome Measures

Primary Outcomes (1)

• Kinetics of 13C-EPA and 13C-AA

  Plasma incorporation of 13C-EPA or 13C-AA was measured from the area under the curve in young and older participants over 28 days post-dose

Study Arms (2)

Young

Six young (18-30 yrs old) healthy participants were recruited. The study had three blocks of one month: 13C-EPA follow-up, wash-out and 13C-AA follow-up. Each participant orally consumed a single oral dose of 35 mg of 13C-EPA, and after the wash-out, a 50 mg dose of 13C-AA.

Other: 13C eicosapentaenoic acid and 13C arachidonic acid

Elderly

Six older (≥ 70 yrs old) healthy participants were recruited. The study had three blocks of one month: 13C-EPA follow-up, wash-out and 13C-AA follow-up. Each participant orally consumed a single oral dose of 35 mg of 13C-EPA, and after the wash-out, a 50 mg dose of 13C-AA.

Other: 13C eicosapentaenoic acid and 13C arachidonic acid

Interventions

13C eicosapentaenoic acid and 13C arachidonic acid OTHER

Each participant orally consumed a single oral dose of 35 mg of 13C-EPA, and after the wash-out, a 50 mg dose of 13C-AA.

Elderly; Young

Eligibility Criteria

• Age: 18 Years+
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Young and elderly healthy participants

You may qualify if:

• six young (18-30 y old) and six older (≥ 70 y old)
• healthy non medicated participants.

You may not qualify if:

• Tobacco,
• malnutrition (assessed from blood albumin, haemoglobin and lipids), -
• participants taking an EPA+DHA supplements or consuming more than 2 fish meals per week,
• severe gastro-intestinal problems,
• medication for diabetes,
• thyroid disease,
• renal failure,
• cancer,
• psychiatric difficulties or depression,
• cardiovascular disease,
• glucose intolerance (\>8 mmol/L in fasted samples)
• chronic immune condition or inflammation (CRP \> 10 mg/l, white cell count),
• recent major surgery or cardiac event,
• dementia,
• ongoing or past severe drug or alcohol abuse,

Sponsors & Collaborators

• Université de Sherbrooke: lead
• Healthy Aging Research Network: collaborator

Related Publications (1)

• Leveille P, Chouinard-Watkins R, Windust A, Lawrence P, Cunnane SC, Brenna JT, Plourde M. Metabolism of uniformly labeled 13C-eicosapentaenoic acid and 13C-arachidonic acid in young and old men. Am J Clin Nutr. 2017 Aug;106(2):467-474. doi: 10.3945/ajcn.117.154708. Epub 2017 Jun 28.

  PMID: 28659301 DERIVED

Biospecimen

Retention: SAMPLES WITH DNA

Fasted blood samples were collected before breakfast (baseline) and thereafter at 2 h, 4 h, 6 h, 24 h, 7 d, 14 d, after the tracer intake.

Study Design

• Study Type: observational
• Observational Model: CASE CROSSOVER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: October 24, 2016
• First Posted: November 7, 2016
• Study Start: August 1, 2015
• Primary Completion: July 1, 2016
• Study Completion: August 1, 2016
• Last Updated: November 7, 2016

Record last verified: 2016-11