Factors Influencing the 3-Year Recurrence of Liver Carcinoma After Surgery

NCT02941861 | Completed DMC

• 1 other identifier: 010/2016
• Study Type: observational
• Target: 67
• Locations: 0 countries
• Sites: N/A

Brief Summary

Objective:

1. 1.To study the factors that influence the 3- year recurrence of liver carcinoma after surgery
2. 2.To study the related factors affecting recurrence of liver carcinoma after surgery

Conditions

Liver Cancer; Recurrence

Keywords

Hepatocellular carcinoma; Cholangiocarcinoma; Recurrence

Outcome Measures

Primary Outcomes (1)

• Recurrence rate of Liver Carcinoma after surgery

  3 years

Study Arms (2)

recurrence rate of HCC after surgery

There were 33 for Hepatocellular carcinoma between February 2010 to December 2013. All patients were staged according to the tumor-node metastasis (TNM) system and appraised by the hospital tumor board conference. After surgery, an attending physician followed up patients by tumor marker and imaging as standard treatment as well as diagnosed its recurrence. In addition, all recurrence cases had standard treatments till the end of life. The survival was classified as the dates between the operation and the death.

Other: Recurrence Rate of HCC after surgery

recurrence rate of CCA after surgery

There were 34 patients underwent liver resection for Cholangiocarcinoma between February 2010 to December 2013. All patients were staged according to the tumor-node metastasis (TNM) system and appraised by the hospital tumor board conference. After surgery, an attending physician followed up patients by tumor marker and imaging as standard treatment as well as diagnosed its recurrence. In addition, all recurrence cases had standard treatments till the end of life. The survival was classified as the dates between the operation and the death.

Other: Recurrence Rate of CCA after surgery

Interventions

Recurrence Rate of HCC after surgery OTHER

Recurrence Rate of HCC after surgery

recurrence rate of HCC after surgery

Recurrence Rate of CCA after surgery OTHER

Recurrence Rate of CCA after surgery

recurrence rate of CCA after surgery

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

There were 33 and 34 patients underwent liver resection for Hepatocellular carcinoma and Cholangiocarcinoma respectively between February 2010 to December 2013. All patients were staged according to the tumor-node metastasis (TNM) system and appraised by the hospital tumor board conference. After surgery, an attending physician followed up patients by tumor marker and imaging as standard treatment as well as diagnosed its recurrence. In addition, all recurrence cases had standard treatments till the end of life. The survival was classified as the dates between the operation and the death.

You may qualify if:

• All patients underwent liver resection for Hepatiocellular carcinoma and Cholangiocarcinoma respectively including having pathology results between February 2010 to December 2013. Data was received from Cholabhron Hospital's patient database.

You may not qualify if:

• All patients having no pathology results were not included.
• All patients having no show for follow up recording were excluded.

Sponsors & Collaborators

• Ruechuta Molek: lead

Related Publications (11)

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  PMID: 10024103 BACKGROUND

• Shimada M, Takenaka K, Taguchi K, Fujiwara Y, Gion T, Kajiyama K, Maeda T, Shirabe K, Yanaga K, Sugimachi K. Prognostic factors after repeat hepatectomy for recurrent hepatocellular carcinoma. Ann Surg. 1998 Jan;227(1):80-5. doi: 10.1097/00000658-199801000-00012.

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  PMID: 8916872 BACKGROUND

• Hasegawa S, Ikai I, Fujii H, Hatano E, Shimahara Y. Surgical resection of hilar cholangiocarcinoma: analysis of survival and postoperative complications. World J Surg. 2007 Jun;31(6):1256-63. doi: 10.1007/s00268-007-9001-y.

  PMID: 17453285 BACKGROUND

• Yusoff AR, Razak MM, Yoong BK, Vijeyasingam R, Siti ZM. Survival analysis of cholangiocarcinoma: a 10-year experience in Malaysia. World J Gastroenterol. 2012 Feb 7;18(5):458-65. doi: 10.3748/wjg.v18.i5.458.

  PMID: 22346252 BACKGROUND

• Hanazaki K, Kajikawa S, Shimozawa N, Mihara M, Shimada K, Hiraguri M, Koide N, Adachi W, Amano J. Survival and recurrence after hepatic resection of 386 consecutive patients with hepatocellular carcinoma. J Am Coll Surg. 2000 Oct;191(4):381-8. doi: 10.1016/s1072-7515(00)00700-6.

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• Wadsworth CA, Dixon PH, Wong JH, Chapman MH, McKay SC, Sharif A, Spalding DR, Pereira SP, Thomas HC, Taylor-Robinson SD, Whittaker J, Williamson C, Khan SA. Genetic factors in the pathogenesis of cholangiocarcinoma. Dig Dis. 2011;29(1):93-7. doi: 10.1159/000324688. Epub 2011 Jun 17.

  PMID: 21691113 BACKGROUND

• Portolani N, Coniglio A, Ghidoni S, Giovanelli M, Benetti A, Tiberio GA, Giulini SM. Early and late recurrence after liver resection for hepatocellular carcinoma: prognostic and therapeutic implications. Ann Surg. 2006 Feb;243(2):229-35. doi: 10.1097/01.sla.0000197706.21803.a1.

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MeSH Terms

Conditions

Liver Neoplasms; Recurrence; Carcinoma, Hepatocellular; Cholangiocarcinoma

Condition Hierarchy (Ancestors)

Digestive System Neoplasms; Neoplasms by Site; Neoplasms; Digestive System Diseases; Liver Diseases; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Adenocarcinoma; Carcinoma; Neoplasms, Glandular and Epithelial; Neoplasms by Histologic Type

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Ms Ruechuta Molek (rmolek)

Study Record Dates

• First Submitted: October 20, 2016
• First Posted: October 21, 2016
• Study Start: August 1, 2016
• Primary Completion: August 1, 2016
• Study Completion: September 1, 2016
• Last Updated: October 21, 2016

Record last verified: 2016-10

Data Sharing

• IPD Sharing: Will share