MRONJ
International, Multicenter, Prospective Registry to Collect Data of Treatment Patterns of Patients With Medication-related Osteonecrosis of the Jaw (MRONJ) and Their Outcome
Sponsor study identifier
observational
518
10 countries
14
Study Start
August 14, 2017
Actual (reported)Primary Completion
October 13, 2023
Actual (reported)Study Completion
April 2024
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Approximately 500 patients will be included in this patient registry. Data collection includes demographics, clinical data of underlying disease and use of bisphosphonates, denosumab and antiangiogenic drugs , degree and extension of osteonecrosis, osteonecrosis-specific treatment, outcomes and complications within 1 year after treatment.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
April 2024
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
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Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
October 12, 2016
Actual (reported)October 13, 2016
Actual (reported)August 14, 2017
Actual (reported)October 13, 2023
Actual (reported)April 2024
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Treatment outcome
Compared to the baseline status of the patient's condition, the outcome will be evaluated as: * Worsening of the osteonecrosis (e.g. size of the lesion increased) * No change of the osteonecrosis * Reduction of the osteonecrosis (e.g. size of the lesion decrease) * Complete mucosa healing
6 months / 1 year
Pain perception
6 months / 1 year
Staging of osteonecrosis
6 months / 1 year
Site and size of the lesion
6 months / 1 year
Patients diagnosed of medication-related osteonecrosis of the jaw (MRONJ). Treatment strategies vary depending on the stage of MRONJ and can be of different nature as: Conservative treatment Surgical treatment Adjuvant non-surgical treatment
Disinfectant mouth rinses, Antibiotic therapy, Antifungal therapy
Superficial debridement, Complete removal of necrotic bone, Complete bone resection, When applicable revision and soft tissue coverage
Patients diagnosed of medication-related osteonecrosis of the jaw (MRONJ)
University of Kentucky Chandler Medical Center
Lexington, Kentucky, 40536, United States
Helsinki University Hospital
Helsinki, 00029, Finland
Charité - Universitätsmedizin Berlin
Berlin, Germany
Universitätskliniken Eppendorf
Hamburg, Germany
Ludwig-Maximilians University Munich, Klinik und Poliklinik für Mund-, Kiefer und Gesichtschirurgie
München, 80337, Germany
Eramus MC
Rotterdam, Netherlands
Hamad Medical Corporation
Doha, Qatar
Risto Kontio, MD DDS PhD
Helsinki University Central Hospital
518 participants (actual enrollment reported by the registry).
First Submitted
October 12, 2016
First Posted
October 13, 2016
Study Start
August 14, 2017
Actual (reported)CSS-Assessing the Course of Degenerative Cervical Spinal Stenosis Using Functional Outcomes
Hyperbaric oxygen therapy Pentoxifylline and tocopherol Ozone therapy Low level laser therapy Pain relief Anti-inflammatory treatment Platelet rich plasma Parathyroid hormone and teriparatide Bone morphogenetic protein
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Contact the study team to confirm eligibility.
Emergency Clinical County Hospital of Constanta
Constanța, Romania
University Medical Centre Ljubljana
Ljubljana, Slovenia
Kyungpool National University
Daegu, South Korea
12 de Octubre University Hospital
Madrid, Spain
Universitätsspital Basel
Basel, 4031, Switzerland
Luzerner Kantonsspital
Lucerne, Switzerland
Universitätsspital Zürich
Zurich, Switzerland
Primary Completion
October 13, 2023
Actual (reported)Study Completion
April 2024
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Last Updated
March 20, 2024
Record last verified: 2024-03
Download the complete ClinicalTrials.gov record imported by Syfrah, including fields not shown in this page. The registry may contain a newer revision.
Source: ClinicalTrials.gov.
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