The Impaction of Exercise Training on Bone Mineral Density in Patients After Total Knee Arthroplasty

NCT02928562 | Completed

• 1 other identifier: CORPG6C0021-23
• Study Type: interventional
• Target: 110
• Locations: 1 country
• Sites: 1

Brief Summary

Rehabilitation after total knee arthroplasty (TKA) should consider control of postoperative pain and swelling, protection of the healing graft, restoration of full range of motion symmetric to the contralateral knee, strengthening of the muscles that stabilize the knee, hip, and trunk, enhancing neuromuscular control, and a gradual progression to functional activities that are required for return to the normal daily life. The effects of concomitant injuries and surgical procedures must also be considered in planning an individualized rehabilitation program. However, it is still unclear regarding the optimal exercise prescription after TKA. In the current study, the investigators plan to develop an exercise protocol and evaluate the result in a multidisciplinary approach, i.e. bone mineral density assessment. The exercise prescription consisted of cyclic exercise, aerobic exercise and resistant training exercise for first, second and third year, respectively. Cyclic exercise is advantaged safety and effectiveness of hydraulic resistance equipment, as well as the exercise can be quantitatively determined. Aerobic exercise is privileged by the cardiopulmonary endurance improvement, along with muscle strengthening in the associated muscle groups. Resistance exercise is specified for the indicated muscle groups, especially knee extensors, flexors, ankle plantar flexor and dorsi flexor in TKA reconstructed patients. The investigators hypothesis that using this cyclic exercise process can improve the body composition, muscle strength, bone mass density, level of oxidative damage indicators, gait performance, quality of life, knee joint range of motion, function of cardiopulmonary and fitness. This project will establish the scientific basis for rehabilitation protocol involving knee surgery.

Conditions

Knee Osteoarthritis; Arthropathy of Knee

Outcome Measures

Primary Outcomes (1)

• Change from baseline bone mineral density

  Bone mineral density measurement is measured by dual-energy x-ray absorptiometry (DXA). Measurements are made over the lumbar spine and over the upper part of the hip and the measurement is assessed at pre-operation, three month, six month and nine month after operation, and twelve-month follow-up.

  pre-operation; three month ; six month and nine month after operation; twelve-month follow-up

Secondary Outcomes (7)

• Change from baseline lower extremity muscle strength

  pre-operation; three month ; six month and nine month after operation; twelve-month follow-up

• Motion analysis

  pre-operation; three month ; six month and nine month after operation; twelve-month follow-up

• Change from baseline SF-36 questionnaire assessment

  pre-operation; three month ; six month and nine month after operation; twelve-month follow-up

• Change from baseline KOOS questionnaire assessment

  pre-operation; three month ; six month and nine month after operation; twelve-month follow-up

• Physical fitness---6-minutes' walk test

  pre-operation; three month , six month and nine month after operation; twelve-month follow-up

Study Arms (2)

Control

NO INTERVENTION

TKA patients without exercise intervention

Exercise

EXPERIMENTAL

TKA patients with exercise intervention ( cyclic exercise, aerobic exercise and resistant training exercise )

Other: exercise

Interventions

exercise OTHER

cyclic exercise, aerobic exercise and resistant training exercise

Exercise

Eligibility Criteria

• Age: 65 Years - 85 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)

Sponsors & Collaborators

• Chang Gung Memorial Hospital: lead

Study Sites (1)

Sports Medicine Center, Chang Gung Memorial Hospital

Chiayi City, 613, Taiwan

Location

Related Publications (1)

• Hsu WH, Hsu WB, Shen WJ, Lin ZR, Chang SH, Hsu RW. Circuit training enhances function in patients undergoing total knee arthroplasty: a retrospective cohort study. J Orthop Surg Res. 2017 Oct 19;12(1):156. doi: 10.1186/s13018-017-0654-4.

  PMID: 29052519 DERIVED

MeSH Terms

Conditions

Osteoarthritis, Knee

Interventions

Exercise

Condition Hierarchy (Ancestors)

Osteoarthritis; Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Robert Wen-Wei HSU, MD

  Sports Medicine Center, Chang Gung Memorial Hospital, Chiayi

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: DOUBLE
• Who Masked: INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Honorary Dean

Study Record Dates

• First Submitted: September 18, 2016
• First Posted: October 10, 2016
• Study Start: October 1, 2013
• Primary Completion: October 31, 2017
• Study Completion: October 31, 2017
• Last Updated: November 9, 2017

Record last verified: 2017-11

Locations

TW (1)