TEXTOO
Impact of Muscular Training Program on Body Composition of Overweight and Obese Teenagers: classi201c Cycling Exercise in Concentric Versus Eccentric
Sponsor study identifier
Secondary identifiers
OTHER · 2016-A00043-48
interventional
25
1 country
1
Study Start
January 1, 2017
Actual (reported)Primary Completion
December 2019
Actual (reported)Study Completion
January 2020
Actual (reported)Nowadays, eccentric exercise can be realized in a dynamic way with an ergocycle which permits eccentric (ECC) lower limbs contractions at a defined power output. With this type of ergometer, O2 consumption (VO2) in ECC is three fold lower than in concentric (CON) for the same power output. Consequently, ECC program could be used in chronic disorders with limited capacities, such as obesity. The investigators hypothesis that an eccentric training program, as it will induce higher mechanical constraints, would improve body composition, especially by reducing fat mass. This effect could be explained by an increased rest energy expenditure and a better improvement in biological parameters (particularly lipid profile and insulin-resistance) after ECC training (versus CON training). This study aims to compare the modification of fat mass after an ECC program versus a CON program at the same VO2.. The secondary goal is to assess the physiological mechanisms involved in the modification of body composition.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
January 2020
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
September 26, 2016
Actual (reported)October 6, 2016
Actual (reported)January 1, 2017
Actual (reported)December 2019
Actual (reported)January 2020
Actual (reported)change in total body fat mass (Dual X ray Absorptiometry)
before and after the 12 weeks training program
aerobic capacities (VO2max)
before and after the 12 weeks training program
isometric muscular lower limbs strength
before and after the 12 weeks training program
isokinetic muscular lower limbs strength
before and after the 12 weeks training program
rest energy expenditure (indirect calorimetry)
before and after the 12 weeks training program
biological parameters (plasma lipid profile and insulin-resistance )
before and after the 12 weeks training program
40 obese adolescents will be randomized into 2 groups: CON or EXC
40 obese adolescents will be randomized into 2 groups: CON or EXC
All measurements are performed before and after the training program (12 weeks)
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
CHU Clermont-Ferrand
Clermont-Ferrand, 63003, France
Julian V, Thivel D, Miguet M, Pereira B, Costes F, Coudeyre E, Duclos M, Richard R. Eccentric cycling is more efficient in reducing fat mass than concentric cycling in adolescents with obesity. Scand J Med Sci Sports. 2019 Jan;29(1):4-15. doi: 10.1111/sms.13301. Epub 2018 Oct 4.
Moore H, Pereira B, Fillon A, Miguet M, Masurier J, Beaulieu K, Finlayson G, Thivel D. The association between obesity severity and food reward in adolescents with obesity: a one-stage individual participant data meta-analysis. Eur J Nutr. 2024 Jun;63(4):1241-1255. doi: 10.1007/s00394-024-03348-4. Epub 2024 Feb 20.
Valérie JULIAN
University Hospital, Clermont-Ferrand
25 participants (actual enrollment reported by the registry).
First Submitted
September 26, 2016
First Posted
October 6, 2016
Study Start
January 1, 2017
Actual (reported)Contact the study team to confirm eligibility.
Julian V, Thivel D, Miguet M, Brengues C, Pereira B, Courteix D, Richard R, Duclos M. Bone response to eccentric versus concentric cycling in adolescents with obesity. Obes Res Clin Pract. 2020 Nov-Dec;14(6):554-560. doi: 10.1016/j.orcp.2020.10.002. Epub 2020 Oct 26.
Primary Completion
December 2019
Actual (reported)Study Completion
January 2020
Actual (reported)Last Updated
August 7, 2026
Record last verified: 2026-08
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Source: ClinicalTrials.gov.
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