LearningRx Cognitive Training for Brain Injury

NCT02918994 | Active Not Recruiting

• 1 other identifier: GICR-0916-B
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this investigation is to conduct a series of case studies on the impact of LearningRx cognitive training on cognitive skills, daily functioning, and workplace self-efficacy for participants with Traumatic Brain Injury (TBI) /Acquired Brain Injury (ABI).

Conditions

Traumatic Brain Injury (TBI); Acquired Brain Injury; Post COVID-19 Cognitive Impairment

Outcome Measures

Primary Outcomes (1)

• Evidence of Change in Workplace Self-Efficacy

  Confirmed by change on 29-item Workplace Self-Efficacy Survey

  Baseline and 9 months

Secondary Outcomes (5)

• Evidence of overall cognitive function improvement

  Baseline and 9 months

• Evidence of Change in Self-Reported Functioning at Home and Work

  Baseline and 9 months

• Evidence of reduction in TBI symptoms

  Baseline and 9 months

• Evidence of change in brain activity

  Baseline and 9 months

• Evidence of change in brain structure

  Baseline and 9 months

Study Arms (1)

LearningRx cognitive training

EXPERIMENTAL

The intervention is a 60-90 hour, clinician-delivered cognitive training program.

Behavioral: LearningRx cognitive training

Interventions

LearningRx cognitive training BEHAVIORAL

A clinician will deliver three 90-minute cognitive training sessions per week for 14 weeks. There are 16 different categories of leveled training procedures sequenced in intensity and difficulty for a total of 530 training tasks. Participants will receive training in-person or remotely depending on state of residence.

LearningRx cognitive training

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• \- Age 18+ previously diagnosed with TBI/ABI

You may not qualify if:

• No braces, metal implants, or claustrophobia that would contraindicate magnetic resonance imaging for participants receiving MRI only

Sponsors & Collaborators

• Gibson Institute of Cognitive Research: lead
• Louisiana State University Health Sciences Center Shreveport: collaborator

Study Sites (1)

Gibson Institute of Cognitive Research

Colorado Springs, Colorado, 80919, United States

Location

Related Publications (1)

• Moore AL, Carpenter DM 2nd, James RL, Miller TM, Moore JJ, Disbrow EA, Ledbetter CR. Neuroimaging and Neuropsychological Outcomes Following Clinician-Delivered Cognitive Training for Six Patients With Mild Brain Injury: A Multiple Case Study. Front Hum Neurosci. 2020 Jun 24;14:229. doi: 10.3389/fnhum.2020.00229. eCollection 2020.

  PMID: 32670040 DERIVED

MeSH Terms

Conditions

Brain Injuries, Traumatic; Brain Injuries

Condition Hierarchy (Ancestors)

Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Craniocerebral Trauma; Trauma, Nervous System; Wounds and Injuries

Study Officials

• Christina Ledbetter, PhD

  Gibson Institute of Cognitive Research and LSU Health Shreveport

  PRINCIPAL INVESTIGATOR

• Amy L Moore, PhD

  Gibson Institute of Cognitive Research

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 27, 2016
• First Posted: September 29, 2016
• Study Start: September 1, 2016
• Primary Completion: September 1, 2025
• Study Completion (Estimated): December 1, 2027
• Last Updated: February 13, 2026

Record last verified: 2026-02

Data Sharing

• IPD Sharing: Will share

Locations

US (1)