Liver and Biliary Tumor Tissue Registry

NCT02917759 | Terminated

• 1 other identifier: 13-006829
• Study Type: observational
• Target: 1,000
• Locations: 1 country
• Sites: 1

Brief Summary

Patients having surgery to remove a liver or biliary tissue mass or having a biopsy of a mass or lesion will have a tissue sample collected and stored for future research of liver and biliary diseases. A blood sample may also be collected at the time of enrollment.

Conditions

Hepatocellular Carcinoma; Cholangiocarcinoma

Keywords

liver cancer; biliary tract cancer; cholangiocarcinoma; hepatocellular carcinoma; liver tumor; biliary tumor; hepatoma; liver mass

Outcome Measures

Primary Outcomes (1)

• Number of successful xenografts established

  The number of successful individual patient derived xenografts that are established beyond the second passage in immunodeficient mice

  6 months

Study Arms (2)

Hepatocellular cancer

Surgical waste tissue will be collected after removal of a liver tumor. A blood sample may be collected at the time of labs related to treatment for the diagnosis. An extra sample of biopsy tissue will be collected from participants having a targeted mass biopsy.

Cholangiocarcinoma

Surgical waste tissue will be collected after removal of a biliary tumor. A blood sample may be collected at the time of labs related to treatment for the diagnosis. An extra sample of biopsy tissue will be collected from participants having a targeted mass biopsy.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Individuals undergoing surgical removal of a liver or biliary mass at Mayo Clinic Florida

You may qualify if:

• Scheduled to undergo surgical resection of a liver or biliary mass

You may not qualify if:

• Under 18 years of age. Prior radiation to mass.

Sponsors & Collaborators

• Mayo Clinic: lead

Study Sites (1)

Mayo Clinic

Jacksonville, Florida, 32224, United States

Location

Related Links

• Mayo Clinic Clinical Trials

Biospecimen

Retention: SAMPLES WITH DNA

whole blood and tissue samples

MeSH Terms

Conditions

Carcinoma, Hepatocellular; Cholangiocarcinoma; Liver Neoplasms; Biliary Tract Neoplasms

Condition Hierarchy (Ancestors)

Adenocarcinoma; Carcinoma; Neoplasms, Glandular and Epithelial; Neoplasms by Histologic Type; Neoplasms; Digestive System Neoplasms; Neoplasms by Site; Digestive System Diseases; Liver Diseases; Biliary Tract Diseases

Study Officials

• Tushar C Patel, MBChB

  Mayo Clinic

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 1 Year
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Consultant

Study Record Dates

• First Submitted: September 24, 2016
• First Posted: September 28, 2016
• Study Start: February 1, 2014
• Primary Completion: December 1, 2025
• Study Completion: December 1, 2025
• Last Updated: January 9, 2026

Record last verified: 2025-04

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)