NCT02906566|CompletedPhase 4Results
Retinol on Human Skin Aging in East Asian Descent
Discovery of Effects of Retinol on Human Skin Aging in Individuals of East Asian Descent
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Sponsor study identifier
interventional
110
1 country
1
Study Start
November 2015
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
March 9, 2018
Actual (reported)Study Completion
March 9, 2018
Actual (reported)There has been increasing evidence for different rates of natural aging in humans and one of the best organs to study human aging is skin. Studies have demonstrated anti-aging effects of topical agents (such as creams, gels, lotions, or ointments) and one of them, retinol or vitamin A, was shown to decrease fine wrinkling in skin of older individuals. Additionally, studies of retinol in humans have largely occurred in white populations and so this study aims to focus on skin aging in individuals of East Asian descent as they represent a majority of the world population. This study aims to better characterize the molecular basis of rejuvenation effects and to potentially discover new topical agents with similar and/or more effective preservation of skin youthfulness.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
March 9, 2018
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
November 2015
Date type not reportedThis date has not been verified as actual or estimated.
February 26, 2016
Actual (reported)September 20, 2016
Actual (reported)March 9, 2018
Actual (reported)March 9, 2018
Actual (reported)April 16, 2019
Actual (reported)Number of Genes Upregulated or Downregulated as Assessed by RNA Sequencing (Older Group, Retinol Versus Placebo)
Differences in transcript levels are reported as the number that were upregulated or downregulated in the participant's retinol-treated arm versus their placebo-treated arm.
Week 12
Number of Genes Upregulated or Downregulated as Assessed by RNA Sequencing (Younger Group Versus Older Group as Baseline)
Differences in transcript levels are reported as the number of genes that were upregulated or downregulated in the Younger Group participant tissue samples, as compared to a baseline provided by tissue samples collected from the Older Group (prior to their treatment).
Week 1
Transepidermal Water Loss
Baseline; Week 12
Severity of Arm Skin Wrinkling
Baseline; Week 12
Elasticity on Arm Skin
Baseline; week 12
Count of Participants With Skin and Subcutaneous Adverse Events as a Measure of Type and Severity of Adverse Events
Baseline through week 12
Active and Placebo. Participants received retinol lotion on one arm and placebo to match on the other arm.
Participants in the group will give tissue sample only for comparison.
Retinol in the form of vitamin A lotion
Placebo of Retinol
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Stanford Dermatology
Redwood City, California, 94603, United States
110 participants (actual enrollment reported by the registry).
First Submitted
February 26, 2016
First Posted
September 20, 2016
Study Start
November 2015
Date type not reportedThis date has not been verified as actual or estimated.
Prospective Study of Topical Adapinoid Versus Topical Retinol
Contact the study team to confirm eligibility.
Primary Completion
March 9, 2018
Actual (reported)Study Completion
March 9, 2018
Actual (reported)Last Updated
April 16, 2019
Results First Posted
April 16, 2019
Record last verified: 2019-03
No current plan to share data.
Download the complete ClinicalTrials.gov record imported by Syfrah, including fields not shown in this page. The registry may contain a newer revision.
Source: ClinicalTrials.gov.
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