Prevalence of Malaria Parasites in People Working in Illegal Gold Mining in French Guiana

NCT02903706 | Completed

• 1 other identifier: ORPAL
• Study Type: observational
• Target: 421
• Locations: 0 countries
• Sites: N/A

Brief Summary

Malaria is the most widespread parasitic illness in the world, and it is endemic to Guiana. Although the number of cases has decreased since 2005, sources of infection still remain, particularly within illegal gold mines. These malaria carriers/sufferers often use self-medication to deal with malaria symptoms, resulting in a risk of resistance to anti-malarial treatments, and particularly to artemisinine. The mobility of this population across the Guiana Shield increases both the risk of malaria spreading and the resistance of this illness to treatment in the region, and puts the population at risk of new outbreaks of this disease despite the great efforts put into anti-malarial policy in this region. Fighting malaria within this population is therefore a dual public health challenge: on the one hand, make it possible for the WHO to eliminate malaria from the Guiana Shield by 2017, on the other to limit resistance to artemisinine in this region. However, Guiana's particular context - namely the illegal status of gold mines and the difficult geographical access, the Harpie military operations, the illegality of carrying out malarial diagnosis tests and treating cases without the presence of a health professional - prevents us from achieving this goal using the same tools as our neighbours in Suriname, whose " Looking for Gold, Finding Malaria " programme was a success. A better understanding of the malarial epidemiology in this population will enable us to propose innovative, more adapted measures to combat malaria within these guyanese populations. This is an transversal, multicentric observational study.

Conditions

Malaria; Epidemiology

Keywords

gold miners; plasmodium carriers; artemisinine resistance

Outcome Measures

Primary Outcomes (1)

• prevalence of malaria positive individuals (symptomatic or not symptomatic)

  every participant gives a capillary blood specimen which is then screened for malaria using PCR in order to obtain a prevalence of malaria positive individuals (symptomatic or not symptomatic)

  1 month

Secondary Outcomes (1)

• Microscopy: thick and thin smear

  1 month

Interventions

Measure of Plasmodium prevalence (PCR) OTHER

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

People working on illegal gold mining sites in French Guiana.

You may qualify if:

• works on a gold mining site in French Guiana
• has been at the resting site for less than seven days
• is over the age of 18
• accepts to take part in this study

You may not qualify if:

• refuses to take part in the study
• is under the age of 18

Sponsors & Collaborators

• Centre Hospitalier de Cayenne: lead

Related Publications (1)

• Douine M, Mosnier E, Le Hingrat Q, Charpentier C, Corlin F, Hureau L, Adenis A, Lazrek Y, Niemetsky F, Aucouturier AL, Demar M, Musset L, Nacher M. Illegal gold miners in French Guiana: a neglected population with poor health. BMC Public Health. 2017 Jul 17;18(1):23. doi: 10.1186/s12889-017-4557-4.

  PMID: 28716015 DERIVED

Biospecimen

Retention: SAMPLES WITHOUT DNA

blood sample (5 ml) for Plasmodium PCR

MeSH Terms

Conditions

Malaria

Interventions

Polymerase Chain Reaction

Condition Hierarchy (Ancestors)

Protozoan Infections; Parasitic Diseases; Infections; Mosquito-Borne Diseases; Vector Borne Diseases

Intervention Hierarchy (Ancestors)

Nucleic Acid Amplification Techniques; Genetic Techniques; Investigative Techniques

Study Design

• Study Type: observational
• Observational Model: CASE CROSSOVER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 7, 2016
• First Posted: September 16, 2016
• Study Start: October 1, 2014
• Primary Completion: June 1, 2015
• Study Completion: June 1, 2015
• Last Updated: September 16, 2016

Record last verified: 2016-09