Interest of New MRI Sequences After Embolization of Brain Arteriovenous Malformations

NCT02896881 | Terminated

• 1 other identifier: RBC_2016_7
• Study Type: observational
• Target: 53
• Locations: 1 country
• Sites: 1

Brief Summary

In previous studies exploring specific sequences of MRI (susceptibility weighted imaging (SWI) and arterial spin labeling (ASL)), the investigators have shown the great sensibility of these MRI sequences to detect arteriovenous shunts, compared to angiography imaging (static or dynamic). This prospective study aims to compare multisequence MRI to brain arteriography imaging in patients undergoing brain arteriovenous malformations embolization.

Conditions

Brain Arteriovenous Malformations

Outcome Measures

Primary Outcomes (1)

• sensitivity of multisequence MRI to detect a residual arteriovenous malformation after embolization

  Early opacification of a vein, possibly associated with the presence of abnormal vessels, will be sought, indicating a residual malformation. After interpretation of the MRI (angio-MRI with multi-sequences, magnetic susceptibility (SWI), arterial spin labelling (ASL) and static or dynamic angiography), the result will be coded dichotomously: (presence/absence of a residual malformation). The arteriography result will be coded in the same way. The sensitivity of the new MRI sequences for detecting a residual arteriovenous malformation after treatment by embolisation will thus be assessed, compared with arteriography (gold-standard).

  within 3 months after embolization

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patient with brain Arteriovenous Malformations and embolization treatment scheduled.

You may qualify if:

• Patient ≥ 18 years old
• with brain Arteriovenous Malformations
• embolization treatment scheduled

You may not qualify if:

• patient's refusal to participate in the study
• contraindication to undergo MRI examination
• patient under legal protection

Sponsors & Collaborators

• Fondation Ophtalmologique Adolphe de Rothschild: lead

Study Sites (1)

Fondation Opthalmologique A de Rothschild

Paris, 75019, France

Location

Study Officials

• Raphaël BLANC, MD

  Fondation Ophtalmologique Adolphe de Rothschild

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: NETWORK
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 7, 2016
• First Posted: September 12, 2016
• Study Start: February 1, 2017
• Primary Completion: February 3, 2025
• Study Completion: February 3, 2025
• Last Updated: January 22, 2026

Record last verified: 2026-01

Locations

FR (1)