Language Function Reorganization in Patients With Arteriovenous Malformations

NCT07537504 | Not Yet Recruiting DMC

• 1 other identifier: KY2025-104-01
• Study Type: observational
• Target: 120
• Locations: 1 country
• Sites: 1

Brief Summary

Brain arteriovenous malformation (AVM) is generally considered as a congenital lesion. Its unique clinical manifestation is that when the unruptured AVM involves and destroys the language function area of the left hemisphere, the patient has almost no language disorder. This phenomenon is distinct from those of acquired diseases such as cerebral infarction and gliomas. There is a hypothesis that it might be associated with that the occurrence of AVM is earlier than period of language learning. Therefore, patients with AVMs involving language areas can be regarded as population whose language areas are congenital "knocked out" but the language functions remain normal, which provide a special model and new insights for language reorganization research. Previous studies have found that the right hemisphere plays an important role in the remodeling of language function in patients with AVMs, but the specific mechanism remains unclear. The purpose of this study is to further elaborate the role of the right cerebral hemisphere in the reorganized language network and the interhemispheric interaction mechanisms in patients with AVMs involving the language areas, using multimodal magnetic resonanceimaging and from multiple dimensions such as functional remodeling, white matter pathway remodeling, structural remodeling, etc., so as to further understand the remodeling mechanism of the Chinese language network after damage of language areas, and also to provide a theoretical basis for the protection of language function in brain network surgery.

Conditions

Brain Arteriovenous Malformations

Keywords

arteriovenous malformations; language; functional magnetic resonance imaging; reorganization; right cerebral hemisphere

Outcome Measures

Primary Outcomes (3)

• Structural MRI (sMRI) Primary Metric

  Cortical thickness of bilateral language-related brain regions (measured via FreeSurfer); intergroup differences between AVM patients and healthy controls

  baseline and three months after surgery

• Functional MRI Secondary Metrics

  Resting-state regional brain activity: Amplitude of Low Frequency Fluctuation (ALFF) and Regional Homogeneity (ReHo) Dynamic effective connectivity (DCM): Excitatory/inhibitory effective connectivity between lesioned left hemisphere and remodeled right hemisphere regions

  baseline and three months after surgery

• Diffusion MRI (dMRI) Primary Metrics

  White matter microstructural integrity: Fractional Anisotropy (FA, DTI) and Neurite Density Index (NDI, NODDI) of language-related white matter tracts Corpus callosum diffusion metrics (FA, NDI) reflecting interhemispheric communication

  baseline and three months after surgery

Secondary Outcomes (1)

• Multimodal Combined & Exploratory Metrics

  baseline and three months after surgery

Study Arms (2)

Healthy Control

Other: MRI

AVM patients

Other: MRI

Interventions

MRI OTHER

All participants underwent MRI scans

AVM patients; Healthy Control

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Healthy Control and AVM patients

You may qualify if:

• AVM located within left-hemisphere language regions
• right-handedness
• native Mandarin Chinese speakers
• age 18-60 years
• high school education or above

You may not qualify if:

• comorbid neurological or psychiatric disorders
• AVM-related intracranial hemorrhage within the past month
• prior AVM treatment

Sponsors & Collaborators

• Beijing Tiantan Hospital: lead

Study Sites (1)

No. 119 South 4th Ring West Road, Fengtai District, Beijing 100070, China

Beijing, China

Location

MeSH Terms

Conditions

Arteriovenous Malformations; Language

Condition Hierarchy (Ancestors)

Vascular Malformations; Cardiovascular Abnormalities; Cardiovascular Diseases; Vascular Diseases; Congenital Abnormalities; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Communication; Behavior

Study Officials

• Xiaofeng Deng

  Brijing Tiantan Hospital

  STUDY CHAIR

Central Study Contacts

Xiaofeng Deng, MD

CONTACT

+8613426341444; windmessenger@126.com

Zekun Han, MM

CONTACT

+8613523485634; ZKHan0810@163.com

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 10, 2026
• First Posted: April 17, 2026
• Study Start: April 20, 2026
• Primary Completion (Estimated): December 31, 2027
• Study Completion (Estimated): December 31, 2027
• Last Updated: April 17, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)