The Effect of When Medication is Taken on Nutritional Status in Hospitalized Patients Older Than 65 Years

NCT02894827 | Completed

• 1 other identifier: VAN WYMELBEKE 2015
• Study Type: observational
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

Polypathology in elderly subjects requires polypharmacy but even though the efficacy of a medication and digestive tolerance are ensured, the medication can be taken a long time from meals to reduce its side-effects. Despite numerous studies that have investigated links between medication and malnutrition, none have assessed the influence of the time the drug is taken on the evolution of the nutritional status of elderly hospitalized persons. So as to identify the best nutritional criterion in hospitalized persons, a retrospective pilot study will be conducted in about thirty patients. Their medication will be recorded and their nutritional status will be evaluated using the Geriatric Nutritional Risk Index (GNRI), albumin, prealbumin levels, weight and the Mini Nutritional Assessment (MNA) short form. This preliminary study will allow us to choose the best nutritional criterion to compare the impact of two strategies for taking medication (post prandial versus pre-prandial) on improving the nutritional status of malnourished elderly hospitalized patients taking multiple drugs.

Conditions

Nutritional Status

Outcome Measures

Primary Outcomes (1)

• MNA short form

  30 days

Secondary Outcomes (1)

• Geriatric Nutritional risk form

  30 days

Study Arms (2)

EMS

Biological: Blood sample; Other: Flow cytometry; Other: western blot

Control

Biological: Blood sample; Other: Flow cytometry; Other: western blot

Interventions

Blood sample BIOLOGICAL

Control; EMS

Flow cytometry OTHER

Control; EMS

western blot OTHER

Control; EMS

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

patients with a stable or controlled acute disease hospitalized in a geriatric follow-up care unit

You may qualify if:

• patients aged 65 years or more.
• patients with a stable or controlled acute disease hospitalized in a geriatric follow-up care unit.
• patients whose life expectancy is greater than 30 days.
• patients able to eat food normally.
• patients able to swallow their medication.
• patients with at least 3 drugs to be taken orally per day, not including oral nutritional supplements.

You may not qualify if:

• patients at the end of life.
• patients whose drugs must be taken before meals like Non-steroid anti-inflammatory drugs (NSAIDs), glinides, oral antidiabetic agents (OAD).
• patients with parenteral and/or enteral nutrition in the period preceding admission to the geriatric unit.
• patients with indications for parental and/or enteral nutrition.

Sponsors & Collaborators

• Centre Hospitalier Universitaire Dijon: lead

Study Sites (1)

CHU Dijon Bourgogne

Dijon, 21079, France

Location

MeSH Terms

Interventions

Blood Specimen Collection; Flow Cytometry; Blotting, Western

Intervention Hierarchy (Ancestors)

Specimen Handling; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Punctures; Surgical Procedures, Operative; Investigative Techniques; Cell Separation; Cytological Techniques; Cytophotometry; Fluorometry; Luminescent Measurements; Photometry; Chemistry Techniques, Analytical; Electrophoresis; Electrochemical Techniques; Immunoblotting; Immunoassay; Immunologic Techniques; Molecular Probe Techniques

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 31, 2016
• First Posted: September 9, 2016
• Primary Completion: September 1, 2015
• Last Updated: September 9, 2016

Record last verified: 2016-09

Locations

FR (1)