Action-effect Anticipation in Patients With Parkinson's Disease : A Study of the Sensory Attenuation Marker.

NCT02894333 | Terminated

• 1 other identifier: JBL_2014-30
• Study Type: observational
• Target: 1
• Locations: 1 country
• Sites: 2

Brief Summary

The ideomotor theory of action control is considered to be central to the understanding of human voluntary action. According to the ideomotor theory, an action is represented in terms of its desired sensory effects and actions are selected by internally activating these effect representations. Recent imagery and behavioral studies showed that this anticipated representation of action-effects triggered a "sensory attenuation", meaning a decrease of perceptive performances or a decrease of sensory event-related potentials (ERP) for an expected event. Thus, the sensory attenuation constitutes a relevant behavioral tool to investigate sensory anticipation impairment in patients with Parkinson's disease. In a behavioral paradigm, patients and matched control participants have to perform a perceptive task on predicted visual action-effects mixed with mispredicted visual action effects. Performances should be better in mispredicted visual action effects for control participants only.

Conditions

Parkinson Disease

Keywords

Parkinson's disease; Action-effect prediction; Sensory attenuation; Voluntary action

Outcome Measures

Primary Outcomes (1)

• median score

  scores measured with the Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS)

  baseline

Study Arms (1)

Patients with Parkinson's disease

Behavioral: behavioral observation

Interventions

behavioral observation BEHAVIORAL

Patients with Parkinson's disease

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

patients with Parkinson's disease

You may qualify if:

• Parkinson's disease
• Normal or corrected vision

You may not qualify if:

• Other pathology or neurological or psychiatric history
• Known pregnancy or breastfeeding
• Absence of affiliation to the French Social Security
• Person under legal protection
• Patient's opposition to participate

Sponsors & Collaborators

• Fondation Ophtalmologique Adolphe de Rothschild: lead

Study Sites (2)

Fondation Adolphe de Rothschild

Paris, 75019, France

Location

Fondation Ophtalmologique Adolphe de Rothschild

Paris, 75019, France

Location

MeSH Terms

Conditions

Parkinson Disease

Interventions

Behavior Observation Techniques

Condition Hierarchy (Ancestors)

Parkinsonian Disorders; Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases

Intervention Hierarchy (Ancestors)

Psychological Techniques; Investigative Techniques; Behavioral Disciplines and Activities

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: NETWORK
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 5, 2016
• First Posted: September 9, 2016
• Study Start: December 1, 2015
• Primary Completion: September 1, 2018
• Study Completion: September 1, 2019
• Last Updated: December 23, 2019

Record last verified: 2019-12

Locations

FR (2)