Dynamic ASPECTS of Internal PRE-ACTIVATION of Effects Sensors of Voluntary ACTION in PARKINSON's Disease

NCT02894320 | Completed

• 1 other identifier: JBL_2014-28
• Study Type: observational
• Target: 28
• Locations: 1 country
• Sites: 1

Brief Summary

The ability to predict sensory effects of people's own motor actions is a key component of Human action realization. Recent studies revealed this anticipation process to be involved in early and late stages of voluntary actions. Nevertheless, the question whether the action-effect anticipation is impacted or not by "motor pathologies", such as the Parkinson's disease, remains unclear. The current study is aimed to clarify this issue by using a subliminal priming paradigm in patients with Parkinson's disease and in matched control participants. Indeed, subliminal primes corresponding to visual action-effects are displayed at different time points before the actions' execution. Results should allow to determine whether or not the action-effect prediction is impaired at different stages of voluntary action in patients with Parkinson's disease.

Conditions

Parkinson's Disease

Keywords

Parkinson's disease; Voluntary action; Action-effect preactivation; Action-effect prediction

Outcome Measures

Primary Outcomes (2)

• Reaction time

  time measured in seconds

  baseline

• error rate

  baseline

Study Arms (2)

Parkinson's disease

Behavioral: Behavioral observation

Healthy subjects

gender and age matched with Parkinson's disease patients, whose data will be extracted from an existing database

Behavioral: Behavioral observation

Interventions

Behavioral observation BEHAVIORAL

Healthy subjects; Parkinson's disease

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

patients with Parkinson's disease, according to the MDS-UPDRS III (Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale), matched for gender and for age with healthy subjects from a database. This database has already been constituted by the CNRS (Centre national de la recherche scientifique, Laboratory of Psychology of Perception - UMR8242).

You may qualify if:

• Adults age 18 years and older
• Parkinson's disease

You may not qualify if:

• Other pathology or neurological or psychiatric history
• Known pregnancy or breastfeeding
• Absence of affiliation to social security or universal health coverage (CMU)
• Person under legal protection
• Patient's opposition to participate

Sponsors & Collaborators

• Fondation Ophtalmologique Adolphe de Rothschild: lead

Study Sites (1)

Fondation Ophtalmologique Adolphe de Rothschild

Paris, 75019, France

Location

MeSH Terms

Conditions

Parkinson Disease

Interventions

Behavior Observation Techniques

Condition Hierarchy (Ancestors)

Parkinsonian Disorders; Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases

Intervention Hierarchy (Ancestors)

Psychological Techniques; Investigative Techniques; Behavioral Disciplines and Activities

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: NETWORK
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 5, 2016
• First Posted: September 9, 2016
• Study Start: March 1, 2015
• Primary Completion: June 1, 2016
• Study Completion: September 1, 2017
• Last Updated: August 31, 2018

Record last verified: 2018-08

Locations

FR (1)