Bone Mass Changes in Anorexia Nervosa Patient Followed During 4 Years

NCT02891356 | Completed

• 2 other identifiers: 2011_382012-A01009-34
• Study Type: observational
• Target: 180
• Locations: 1 country
• Sites: 1

Brief Summary

The mechanism of bone loss in anorexia nervosa is complex. Marrow adipose tissue seems to play a role in the regulation of bone metabolism. Adipocytes secrete cytokines and adipokines that either stimulate or inhibit adjacent osteoblasts. This study consist to explore the relationship in anorexia nervosa patients with change in bone mineral density and adipokines like leptin, adiponectin and Préf-1 Bone mineral densities will be measure in 180 anorexia nervosa patients at inclusion and every two years during 6 years.It is assessed blood and urinary calcium and phosphate levels, bone remodelling markers and adipokines (leptin, adiponectin and Préf-1)

Conditions

Anorexia Nervosa; Osteoporosis

Keywords

Adiponectin; Bone remodelling markers

Outcome Measures

Primary Outcomes (1)

• Bone mineral density by Dual Energy X-ray Absorptiometry (DEXA)

  measured the evolution of the bone mineral density in 180 anorexia nervosa patients and the relationship with this change and adipokine

  4 years

Secondary Outcomes (3)

• Incidence of osteoporotic fractures

  at 2,4 and 6 years

• Adiponectin plasma concentration by ELISA

  at 2,4 and 6 years

• Interleukin-7 plasma concentration by ELISA

  at 2,4 and 6 years

Study Arms (1)

Anorexia patient

Dual Energy X-ray Absorptiometry (DEXA)

Device: DEXA

Interventions

DEXA DEVICE

The Dual Energy X-ray Absorptiometry (DEXA) is a third generation multi-captor DEXA device that allow short duration measurements. It measures Bone Mineral Density (BMD) at the spine and the femoral neck

Anorexia patient

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Anorexia patient recruted in psychiatric unit ( hospitalisation and consultation visit)

You may qualify if:

• anorexia patient defined by DSM IV diagnostic criteria

You may not qualify if:

• patient with other psychiatric disease
• patient with other a metabolic bone disease

Sponsors & Collaborators

• University Hospital, Lille: lead

Study Sites (1)

Hôpital Roger Salengro, CHRU de Lille

Lille, France

Location

MeSH Terms

Conditions

Anorexia Nervosa; Osteoporosis

Condition Hierarchy (Ancestors)

Feeding and Eating Disorders; Mental Disorders; Bone Diseases, Metabolic; Bone Diseases; Musculoskeletal Diseases; Metabolic Diseases; Nutritional and Metabolic Diseases

Study Officials

• Isabelle LEGROUX, MD

  University Hospital, Lille

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 1, 2016
• First Posted: September 7, 2016
• Study Start: July 1, 2013
• Primary Completion: December 1, 2022
• Study Completion: December 1, 2022
• Last Updated: December 8, 2025

Record last verified: 2025-11

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)